Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/52384
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorGentilcore, D.en
dc.contributor.authorMeyer, J.en
dc.contributor.authorRayner, C.en
dc.contributor.authorHorowitz, M.en
dc.contributor.authorJones, K.en
dc.date.issued2008en
dc.identifier.citationAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology, 2008; 295(2):R472-R477en
dc.identifier.issn0363-6119en
dc.identifier.issn1522-1490en
dc.identifier.urihttp://hdl.handle.net/2440/52384-
dc.descriptionCopyright © 2008 by the American Physiological Society.en
dc.description.abstractPostprandial hypotension occurs frequently, and current management is suboptimal. Recent studies suggest that the magnitude of the fall in postprandial blood pressure (BP) may be attenuated by gastric distension. The aim of this study was to determine the effect of gastric distension on the hypotensive response to intraduodenal (ID) glucose. Eight healthy subjects (5 males, 3 females, aged 65–76 years) received an ID infusion of either 1) 50 g glucose in 300 ml saline (ID glucose) over 60 min (t = 0–60 min), 2) 50 g glucose in 300 ml saline over 60 min and intragastric (4) infusion of 500 ml water between t = 7–10 min (IG water and ID glucose), or 3) ID saline (0.9%) infusion over 60 min and IG infusion of 500 ml water (IG water and ID saline) all followed by ID saline infusion for another 60 min (t = 60–120 min) on three separate days. BP and heart rate (HR) were measured. Gastric emptying (GE) of the IG water was quantified by two-dimensional ultrasonography. Between t = 0–60 min, systolic and diastolic BP was greater (P < 0.05 for both) with IG water and ID saline compared with IG water and ID glucose, and less (P < 0.05 for both) with ID glucose compared with IG water and ID glucose. These effects were evident at relatively low IG volumes (300 ml). GE was faster with IG water and ID saline when compared with IG water and ID glucose. We conclude that, in healthy older subjects, IG administration of water markedly attenuates the hypotensive response to ID glucose, presumably as a result of gastric distension.en
dc.description.statementofresponsibilityDiana Gentilcore, James H. Meyer, Christopher K. Rayner, Michael Horowitz, and Karen L. Jonesen
dc.language.isoenen
dc.publisherAmer Physiological Socen
dc.subjectblood pressure; heart rate; gastric emptying; two-dimensional ultrasound; elderlyen
dc.titleGastric distension attenuates the hypotensive effect of intraduodenal glucose in healthy older subjectsen
dc.typeJournal articleen
dc.identifier.rmid0020080673en
dc.identifier.doi10.1152/ajpregu.00108.2008en
dc.identifier.pubid43399-
pubs.library.collectionMedicine publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
dc.identifier.orcidRayner, C. [0000-0002-5527-256X]en
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]en
dc.identifier.orcidJones, K. [0000-0002-1155-5816]en
Appears in Collections:Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.