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Type: Journal article
Title: Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development
Author: Manning, J.
Colussi, P.
Koblar, S.
Kumar, S.
Citation: Histochemistry and Cell Biology, 2008; 129(6):751-764
Publisher: Springer-Verlag
Issue Date: 2008
ISSN: 0948-6143
Statement of
Jantina A. Manning, Paul A. Colussi, Simon A. Koblar and Sharad Kumar
Abstract: As the primary microtubule-organizing centre of the mammalian cell, the centrosome plays many important roles during cell growth and organization. This is evident across a broad range of cell types and processes, such as the proliferation, differentiation and polarity of neural cells. Additionally, given its localization and function, there are likely to be many more processes that rely on the centrosome that have not yet been characterized. Currently, little is known about centrosomal dynamics during mammalian development. In this study, we have analyzed Nedd1 protein expression to characterize the localization of the centrosome during some aspects of mouse embryogenesis. Using a Nedd1 antibody we have demonstrated the colocalization of Nedd1 with centrosomal markers. We found strong expression of Nedd1, and therefore the centrosome, in highly proliferating cells during neural development. Additionally, Nedd1 was found to have high expression in the cytoplasm of a subset of cells in the dorsal root ganglia. We have also shown a distinct, polarized centrosomal localization of Nedd1 in the developing lens, retina and other polarized tissues. This study reveals the localization of Nedd1 and the centrosome during important processes in mouse embryogenesis and provides a basis for further study into its role in development.
Keywords: Nedd1
Description: The original publication can be found at
DOI: 10.1007/s00418-008-0392-0
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