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dc.contributor.authorThomson, R.-
dc.contributor.authorBuckley, J.-
dc.contributor.authorNoakes, M.-
dc.contributor.authorClifton, P.-
dc.contributor.authorNorman, R.-
dc.contributor.authorBrinkworth, G.-
dc.identifier.citationJournal of Clinical Endocrinology and Metabolism, 2008; 93(9):3373-3380-
dc.description.abstractContext: In overweight women with polycystic ovary syndrome (PCOS), the benefits of the addition of exercise to an energy-restricted diet in further improving cardiometabolic risk factors and reproductive function has not been extensively studied. Objective: The objective was to evaluate the effects of aerobic and aerobic-resistance exercise when combined with an energy-restricted high protein diet (5000–6000 kJ/d) on metabolic risk factors and reproductive function in women with PCOS. Design and Setting: A 20-wk outpatient, randomized, parallel study was conducted in a metropolitan research clinic. Patients and Intervention: Ninety-four overweight and obese women with PCOS (age 29.3 ± 0.7 yr; body mass index 36.1 ± 0.5 kg/m2) were randomized to diet only (DO; n = 30), diet and aerobic exercise (DA; n = 31), or diet and combined aerobic-resistance exercise (DC; n = 33). Main Outcome Measures: Weight, body composition, cardiometabolic risk factors, hormonal status, menstrual cyclicity, and ovulatory function were assessed. Results: All interventions reduced weight (DO 8.9 ± 1.6%, DA 10.6 ± 1.7%, and DC 8.7 ± 1.7%; P < 0.001) with no difference between treatments (P = 0.7, time x treatment). Fat mass decreased more (3 kg) and fat-free mass decreased less (2 kg) in DA and DC compared with DO (P ≤ 0.03). Reductions in blood pressure (5.6/2.7 mm Hg), triglycerides (0.4 mmol/liter), total cholesterol (0.5 mmol/liter), low-density lipoprotein cholesterol (0.1 mmol/liter), glucose (0.2 mmol/liter), fasting insulin (4.3 mIU/liter), testosterone (0.4 nmol/liter), and free androgen index (2.8) (P < 0.001) and improvements in SHBG (7.0 nmol/liter) and reproductive function occurred in all groups, with no difference between treatments. Conclusion: In overweight and obese women with PCOS, the addition of aerobic or combined aerobic-resistance exercise to an energy-restricted diet improved body composition but had no additional effect on improvements in cardiometabolic, hormonal, and reproductive outcomes relative to diet alone.-
dc.description.statementofresponsibilityRebecca L. Thomson, Jonathan D. Buckley, Manny Noakes, Peter M. Clifton, Robert J. Norman and Grant D. Brinkworth-
dc.publisherEndocrine Society-
dc.subjectPolycystic Ovary Syndrome-
dc.subjectCardiovascular Diseases-
dc.subjectTreatment Outcome-
dc.subjectCombined Modality Therapy-
dc.subjectExercise Therapy-
dc.subjectCaloric Restriction-
dc.subjectDiet, Reducing-
dc.subjectRisk Factors-
dc.subjectLife Style-
dc.subjectBody Composition-
dc.titleThe effect of a hypocaloric diet with and without exercise training on body composition, cardiometabolic risk profile, and reproductive function in overweight and obese women with polycystic ovary syndrome-
dc.typeJournal article-
dc.identifier.orcidThomson, R. [0000-0002-7807-4144]-
dc.identifier.orcidClifton, P. [0000-0002-6411-626X]-
dc.identifier.orcidNorman, R. [0000-0002-3118-3896]-
Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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