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dc.contributor.authorMcCowan, L.-
dc.contributor.authorDekker, G.-
dc.contributor.authorChan, E.-
dc.contributor.authorStewart, A.-
dc.contributor.authorChappell, L.-
dc.contributor.authorHunter, M.-
dc.contributor.authorMoss-Morris, R.-
dc.contributor.authorNorth, R.-
dc.identifier.citationBMJ: British Medical Journal, 2009; 338(7710):1-6-
dc.description.abstract<h4>Objectives</h4>To compare pregnancy outcomes between women who stopped smoking in early pregnancy and those who either did not smoke in pregnancy or continued to smoke.<h4>Design</h4>Prospective cohort study.<h4>Setting</h4>Auckland, New Zealand and Adelaide, Australia.<h4>Participants</h4>2504 nulliparous women participating in the Screening for Pregnancy Endpoints (SCOPE) study grouped by maternal smoking status at 15 (+/-1) week's gestation.<h4>Main outcome measures</h4>Spontaneous preterm birth and small for gestational age infants (birth weight <10th customised centile). We compared odds of these outcomes between stopped smokers and non-smokers, and between current smokers and stopped smokers, using logistic regression, adjusting for demographic and clinical risk factors.<h4>Results</h4>80% (n=1992) of women were non-smokers, 10% (n=261) had stopped smoking, and 10% (n=251) were current smokers. We noted no differences in rates of spontaneous preterm birth (4%, n=88 v 4%, n=10; adjusted odds ratio 1.03, 95% confidence interval l0.49 to 2.18; P=0.66) or small for gestational age infants (10%, n=195 v 10%, n=27; 1.06, 0.67 to 1.68; P=0.8) between non-smokers and stopped smokers. Current smokers had higher rates of spontaneous preterm birth (10%, n=25 v 4%, n=10; 3.21, 1.42 to 7.23; P=0.006) and small for gestational age infants (17%, n=42 v 10%, n=27; 1.76, 1.03 to 3.02; P=0.03) than stopped smokers.<h4>Conclusion</h4>In women who stopped smoking before 15 weeks' gestation, rates of spontaneous preterm birth and small for gestational age infants did not differ from those in non-smokers, indicating that these severe adverse effects of smoking may be reversible if smoking is stopped early in pregnancy.-
dc.description.statementofresponsibilityLesley M E McCowan, Gustaaf A Dekker, Eliza Chan, Alistair Stewart, Lucy C Chappell, Misty Hunter, Rona Moss-Morris and Robyn A North-
dc.publisherBritish Med Journal Publ Group-
dc.subjectSCOPE consortium-
dc.subjectPremature Birth-
dc.subjectPregnancy Outcome-
dc.subjectProspective Studies-
dc.subjectSmoking Cessation-
dc.subjectPregnancy Trimester, First-
dc.subjectInfant, Newborn-
dc.subjectInfant, Small for Gestational Age-
dc.titleSpontaneous preterm birth and small for gestational age infants in women who stop smoking early in pregnancy: prospective cohort study-
dc.typeJournal article-
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]-
Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

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