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Type: Journal article
Title: Roles of Wnt signalling in bone growth, remodelling, skeletal disorders and fracture repair
Author: Pyragius, C.
Foster, B.
Xian, C.
Citation: Journal of Cellular Physiology, 2008; 215(3):578-587
Publisher: Wiley-Liss
Issue Date: 2008
ISSN: 0021-9541
Statement of
Carmen E. Macsai, Bruce K. Foster and Cory J. Xian
Abstract: Wnt signalling has an essential role in regulating bone formation and remodelling during embryonic development and throughout postnatal and adult life. Specifically, Wnt signalling regulates bone formation by controlling embryonic cartilage development and postnatal chondrogenesis, osteoblastogenesis, osteoclastogenesis, endochondral bone formation, and bone remodelling. Abnormalities in the function of Wnt genes give rise to or contribute to the development of several pathological bone conditions, including abnormal bone mass, osteosarcomas and bone loss in multiple myeloma. Furthermore, Wnt signalling is activated during bone fracture repair and plays a crucial role in regulating bone regeneration.
Keywords: Animals
Bone Remodeling
Wound Healing
Signal Transduction
Bone Development
Fractures, Bone
Wnt Proteins
DOI: 10.1002/jcp.21342
Appears in Collections:Aurora harvest
Paediatrics publications

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