Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/52663
Citations
Scopus Web of Science® Altmetric
?
?
Type: Journal article
Title: Elastic fibers enhance the mechanical integrity of the human lumbar anulus fibrosus in the radial direction
Author: Smith, L.
Byers, S.
Costi, J.
Fazzalari, N.
Citation: Annals of Biomedical Engineering, 2008; 36(2):214-223
Publisher: Amer Inst Physics
Issue Date: 2008
ISSN: 0090-6964
1573-9686
Statement of
Responsibility: 
Lachlan J. Smith, Sharon Byers, John J. Costi and Nicola L. Fazzalari
Abstract: The anulus fibrosus of the human lumbar intervertebral disc has a complex, hierarchical structure comprised of collagens, proteoglycans, and elastic fibers. Recent histological studies have suggested that the elastic fiber network may play an important functional role. In this study, it was hypothesized that elastic fibers enhance the mechanical integrity of the extracellular matrix in the radial orientation, perpendicular to the plane containing the collagen fibers. Using a combination of biochemically verified enzymatic treatments and biomechanical tests, it was demonstrated that degradation of elastic fibers resulted in a significant reduction in both the initial modulus and the ultimate modulus, and a significant increase in the extensibility, of radially oriented anulus fibrosus specimens. Separate treatments and mechanical tests were used to account for any changes attributable to non-specific degradation of glycosaminoglycans. Additionally, histological assessments provided a unique perspective on structural changes in the elastic fiber network in radially oriented specimens subjected to tensile deformations. The results of this study demonstrate that elastic fibers play an important and unique role in the mechanical properties of the anulus fibrosus, and provide the basis for the development of improved material models to describe intervertebral disc mechanical behavior.
Keywords: Intervertebral disc; Anulus fibrosus; Elastic fibers; Elastin; Structure–function
Description: The original publication can be found at www.springerlink.com
RMID: 0020080120
DOI: 10.1007/s10439-007-9421-8
Appears in Collections:Pathology publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.