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https://hdl.handle.net/2440/53181
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dc.contributor.author | Sferruzzi-Perri, A. | - |
dc.contributor.author | Owens, J. | - |
dc.contributor.author | Standen, P. | - |
dc.contributor.author | Roberts, C. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Placenta, 2008; 29(4):347-355 | - |
dc.identifier.issn | 0143-4004 | - |
dc.identifier.issn | 1532-3102 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53181 | - |
dc.description | Copyright © 2008 Elsevier Ltd All rights reserved. | - |
dc.description.abstract | In guinea pigs, maternal insulin-like growth factor (IGF) infusion in early-pregnancy enhances placental transport near-term, increasing fetal growth and survival. The effects of IGF-II, but not IGF-I, appear due to enhanced placental labyrinthine (exchange) development. To determine if the type-2 IGF receptor (IGF2R) mediates these distinct actions of exogenous IGF-II in the mother, we compared the impact of IGF-II with an IGF-II analogue, Leu(27)-IGF-II, which only binds the IGF2R. IGF-II, Leu(27)-IGF-II (1mg/kg per day.sc) or vehicle were infused from days 20-38 of pregnancy (term = 67 days) and placental structure and uptake and transfer of [(3)H]-methyl-D-glucose (MG) and [(14)C]-amino-isobutyric acid (AIB) and fetal growth and plasma metabolites, were measured on day 62. Both IGF-II and Leu(27)-IGF-II increased the volume of placental labyrinth, trophoblast and maternal blood space within the labyrinth and total surface area of trophoblast for exchange, compared to vehicle. Leu(27)-IGF-II also reduced the barrier to diffusion (trophoblast thickness) compared to vehicle and IGF-II. Both IGF-II and Leu(27)-IGF-II increased fetal plasma amino acid concentrations and placental transfer of MG to the fetus compared to vehicle, with Leu(27)-IGF-II also increasing AIB transport compared with vehicle and IGF-II. In addition, Leu(27)-IGF-II increased fetal weight compared to vehicle. In conclusion, maternal treatment with IGF-II or Leu(27)-IGF-II in early gestation, induce similar placental and fetal outcomes near term. This suggests that maternal IGF-II in early gestation acts in part via the IGF2R to persistently enhance placental functional development and nutrient delivery and promote fetal growth. | - |
dc.description.statementofresponsibility | A.N. Sferruzzi-Perri, J.A. Owens, P. Standen and C.T. Roberts | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/623064/description#description | - |
dc.language.iso | en | - |
dc.publisher | W B Saunders Co Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/j.placenta.2008.01.009 | - |
dc.subject | Blood Vessels | - |
dc.subject | Adipose Tissue | - |
dc.subject | Trophoblasts | - |
dc.subject | Fetus | - |
dc.subject | Placenta | - |
dc.subject | Animals | - |
dc.subject | Guinea Pigs | - |
dc.subject | Body Weight | - |
dc.subject | Fetal Weight | - |
dc.subject | Aminoisobutyric Acids | - |
dc.subject | 3-O-Methylglucose | - |
dc.subject | Amino Acids | - |
dc.subject | Insulin-Like Growth Factor II | - |
dc.subject | Receptor, IGF Type 2 | - |
dc.subject | Organ Size | - |
dc.subject | Body Composition | - |
dc.subject | Biological Transport | - |
dc.subject | Pregnancy | - |
dc.subject | Maternal-Fetal Exchange | - |
dc.subject | Placentation | - |
dc.subject | Litter Size | - |
dc.subject | Female | - |
dc.title | Maternal insulin-like growth factor-II promotes placental functional development via the type 2 IGF receptor in the guinea pig | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.placenta.2008.01.009 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Owens, J. [0000-0002-7498-1353] | - |
dc.identifier.orcid | Roberts, C. [0000-0002-9250-2192] | - |
Appears in Collections: | Aurora harvest 5 Obstetrics and Gynaecology publications |
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