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Type: Journal article
Title: Regional cerebral blood flow in fibromyalgia Single-photon-emission computed tomography evidence of reduction in the pontine tegmentum and thalami
Author: Kwiatek, R.
Barnden, L.
Tedman, R.
Jarrett, R.
Chew, J.
Rowe, C.
Pile, K.
Citation: Arthritis and Rheumatism, 2000; 43(12):2823-2833
Publisher: Wiley-Liss
Issue Date: 2000
ISSN: 0004-3591
Statement of
Richard Kwiatek, Leighton Barnden, Raymond Tedman, Richard Jarrett, Jenni Chew, Christopher Rowe, Kevin Pile
Abstract: To determine whether regional cerebral blood flow (rCBF) is abnormal in any cerebral structure of women with fibromyalgia (FM), following a report that rCBF is reduced in the thalami and heads of caudate nuclei in FM. Methods Seventeen women with FM and 22 healthy women had a resting single-photon–emission computed tomography (SPECT) brain scan to assess rCBF and a T1-weighted magnetic resonance imaging (MRI) scan to enable precise anatomic localization. Additionally, all participants underwent 2 manual tender point examinations and completed a set of questionnaires evaluating clinical features. SPECT scans were analyzed for differences in rCBF between groups using statistical parametric mapping (SPM) and regions of interest (ROIs) manually drawn on coregistered MRI. Results Compared with control subjects, the rCBF in FM patients was significantly reduced in the right thalamus (P = 0.006), but not in the left thalamus or head of either caudate nucleus. SPM analysis indicated a statistically significant reduction in rCBF in the inferior pontine tegmentum (corrected P = 0.006 at the cluster level and corrected P = 0.023 for voxel of maximal significance), with consistent findings from ROI analysis (P = 0.003). SPM also detected a reduction in rCBF on the perimeter of the right lentiform nucleus. No correlations were found with clinical features or indices of pain threshold. Conclusion Our finding of a reduction in thalamic rCBF is consistent with findings of functional brain imaging studies of other chronic clinical pain syndromes, while our finding of reduced pontine tegmental rCBF is new. The pathophysiologic significance of these changes in FM remains to be elucidated.
Keywords: Tegmentum Mesencephali
Tomography, Emission-Computed, Single-Photon
Analysis of Variance
Cerebrovascular Circulation
Description: Copyright © 2009 American College of Rheumatology The definitive version may be found at
Provenance: Published Online: 26 Mar 2001
DOI: 10.1002/1529-0131(200012)43:12<2823::AID-ANR24>3.0.CO;2-E
Published version:;2-e
Appears in Collections:Anatomical Sciences publications
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