Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/53203
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Type: Journal article
Title: The role of stretch-activated channels in atrial fibrillation and the impact of intracellular acidosis
Author: Ninio, D.
Saint, D.
Citation: Progress in Biophysics & Molecular Biology, 2008; 97(2-3):401-416
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2008
ISSN: 0079-6107
1873-1732
Statement of
Responsibility: 
Daniel M. Ninio and David A. Saint
Abstract: The incidence of atrial fibrillation correlates with increasing atrial size. The electrical consequences of atrial stretch contribute to both the initiation and maintenance of atrial fibrillation. It is suggested that altered calcium handling and stretch-activated channel activity could explain the experimental findings of stretch-induced depolarisation, shortened refractoriness, slowed conduction and increased heterogeneity of refractoriness and conduction. Stretch-activated channel blocking agents protect against these pro-arrhythmic effects. Gadolinium, GsMTx-4 toxin and streptomycin prevent the stretch-related vulnerability to atrial fibrillation without altering the drop in refractory period associated with stretch. Changes the activity of two-pore K+ channels, which are sensitive to stretch and pH but not gadolinium, could underlie the drop in refractoriness. Intracellular acidosis induced with propionate amplified the change in refractoriness with stretch in the isolated rabbit heart model in keeping with the clinical observation of increased propensity to atrial fibrillation with acidosis. We propose that activation of non-specific cation stretch-activated channels provides the triggers for acute atrial fibrillation with high atrial pressure while activation of atrial two-pore K+ channels shortens atrial refractory period and increases heterogeneity of refractoriness, providing the substrate for atrial fibrillation to be sustained. Stretch-activated channel blockade represents an exciting target for future antiarrhythmic drugs.
Keywords: Atrial fibrillation; Acidosis; Stretch-activated channels; Mechano-electric feedback
RMID: 0020081665
DOI: 10.1016/j.pbiomolbio.2008.02.016
Appears in Collections:Physiology publications

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