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|Title:||Prenatal induced chronic dietary hypothyroidism delays but does not block adult-type Leydig cell development|
Anand Ivell, R.
|Citation:||American Journal of Physiology-Endocrinology and Metabolism, 2009; 296(2):E305-E314|
|Publisher:||Amer Physiological Soc|
|Eddy Rijntjes, Hans J. M. Swarts, Ravinder Anand-Ivell, and Katja J. Teerds|
|Abstract:||Transient hypothyroidism induced by propyl-2-thiouracyl blocks postpartum Leydig cell development. In the present study, the effects of chronic hypothyroidism on the formation of this adult-type Leydig cell population were investigated, using a more physiological approach. Before mating, dams were put on a diet consisting of an iodide-poor feed supplemented with a low dose of perchlorate and, with their offspring, were kept on this diet until death. In the pups at day 12 postpartum, plasma thyroid-stimulating hormone levels were increased by 20-fold, whereas thyroxine and free tri-iodothyronine levels were severely depressed, confirming a hypothyroid condition. Adult-type progenitor Leydig cell formation and proliferation were reduced by 40–60% on days 16 and 28 postpartum. This was followed by increased Leydig cell proliferation at later ages, suggesting a possible slower developmental onset of the adult-type Leydig cell population under hypothyroid conditions. Testosterone levels were increased 2- to 10-fold in the hypothyroid animals between days 21 and 42 postpartum compared with the age-matched controls. Combined with the decreased presence of 5α-reductase, this implicates a lower production capacity of 5α-reduced androgens. In 84-day-old rats, after correction for body weight-to-testis weight ratio, plasma insulin-like factor-3 levels were 35% lower in the hypothyroid animals, suggestive of a reduced Leydig cell population. This is confirmed by a 37% reduction in the Sertoli cell-to-Leydig cell ratio in hypothyroid rats. In conclusion, we show that dietary-induced hypothyroidism delays but, unlike propyl-2-thiouracyl, does not block the development of the adult-type Leydig cell population.|
|Keywords:||thyroxine; testosterone; insulin-like factor-3; Leydig cell proliferation|
|Appears in Collections:||Molecular and Biomedical Science publications|
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