Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/53261
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Diener, K. | - |
dc.contributor.author | Lousberg, E. | - |
dc.contributor.author | Beukema, E. | - |
dc.contributor.author | Yu, A. | - |
dc.contributor.author | Howley, P. | - |
dc.contributor.author | Brown, M. | - |
dc.contributor.author | Hayball, J. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Vaccine, 2008; 26(29-30):3566-3573 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.issn | 1873-2518 | - |
dc.identifier.uri | http://hdl.handle.net/2440/53261 | - |
dc.description | Copyright © 2008 Elsevier Ltd All rights reserved. | - |
dc.description.abstract | Recombinant fowlpox viruses (FPVs) have been used in a variety of vaccine strategies; however strong data clearly demonstrating the characteristics of the strength and nature of the resultant immune response elicited by these vectors are lacking. By utilising a recombinant variant of FPV which expresses the nominal antigen chicken ovalbumin (OVA), and assessing innate FPV- and OVA-specific adaptive immune responses, we show that recombinant FPV induces a rapid type I interferon (IFN) response, mediated primarily by plasmacytoid dendritic cells (pDCs). These cells are necessary for the development of a strong but transient CD8(+) T cell effector response directed against OVA-expressing target cells. We propose that a combination of suboptimal type I IFN production, poor CD4(+) T cell helper function and inefficient DC licensing likely contribute to this transient response. These findings now provide a sound basis for rational modifications to be made to recombinant FPV, designed to improve subsequent vaccine responses. | - |
dc.description.statementofresponsibility | Kerrilyn R. Diener, Erin L. Lousberg, Emma L. Beukema, Anastasia Yu, Paul M. Howley, Michael P. Brown and John D. Hayball | - |
dc.description.uri | http://www.elsevier.com/wps/find/journaldescription.cws_home/30521/description#description | - |
dc.language.iso | en | - |
dc.publisher | Elsevier Sci Ltd | - |
dc.source.uri | http://dx.doi.org/10.1016/j.vaccine.2008.05.015 | - |
dc.subject | Dendritic Cells | - |
dc.subject | CD4-Positive T-Lymphocytes | - |
dc.subject | T-Lymphocytes, Helper-Inducer | - |
dc.subject | T-Lymphocytes, Cytotoxic | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Mice | - |
dc.subject | Fowlpox virus | - |
dc.subject | Ovalbumin | - |
dc.subject | Vaccines, Synthetic | - |
dc.subject | Viral Vaccines | - |
dc.subject | Interferon-gamma | - |
dc.title | Recombinant fowlpox virus elicits transient cytotoxic T cell responses due to suboptimal innate recognition and recruitment of T cell help | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.vaccine.2008.05.015 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Diener, K. [0000-0001-8417-5542] | - |
dc.identifier.orcid | Brown, M. [0000-0002-5796-1932] [0000-0002-6678-1407] | - |
dc.identifier.orcid | Hayball, J. [0000-0002-3089-4506] | - |
Appears in Collections: | Aurora harvest Medicine publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.