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Type: Journal article
Title: Relationship between calcium absorption and plasma dehydroepiandrosterone sulphate (DHEAS) in healthy males
Author: Chen, R.
Nordin, B.
Needs, A.
Scopacasa, F.
Wishart, J.
Morris, H.
Horowitz, M.
Citation: Clinical Endocrinology, 2008; 69(6):864-869
Publisher: Blackwell Science Ltd
Issue Date: 2008
ISSN: 0300-0664
Statement of
R.Y.T. Chen, B.E.C. Nordin, A.G. Need, F. Scopacasa, J. Wishart, H.A. Morris and M. Horowitz
Abstract: <h4>Context</h4>Impaired gut sensitivity to 1,25-dihydroxyvitamin D (1,25(OH)(2)D), leading to reduced intestinal calcium absorption, has been reported in older men and women. While this phenomenon in postmenopausal women has been attributed to oestrogen deficiency, it is unclear whether the same observation in older men correlates with the age-related decline in androgen concentrations.<h4>Objective</h4>To examine the relationship between androgens and intestinal calcium absorption in older men.<h4>Design</h4>Cross-sectional study on 55 healthy male volunteers, divided into younger (n = 27) and older (n = 28) groups separated according to the median age of 59 years.<h4>Main outcome measures</h4>Calcium absorption, total and free (calculated) testosterone, dehydroepiandrosterone sulphate (DHEAS), SHBG, and 1,25(OH)(2)D, among others, were measured.<h4>Results</h4>Calcium absorption, free testosterone and DHEAS, but not 1,25(OH)(2)D, declined significantly with age. After adjusting for age and body mass index, stepwise regression showed that 1,25(OH)(2)D and serum albumin were the only significant determinants of calcium absorption in younger men, while the sole determinant in older men was DHEAS, not testosterone. Residual deviations from the regression of calcium absorption on 1,25(OH)(2)D, reflecting the efficiency of 1,25(OH)(2)D-induced calcium absorption, was positively correlated with DHEAS (r = 0.27, P = 0.027).<h4>Conclusions</h4>DHEAS is an independent determinant of calcium absorption in older men, although its manner of influence is, as yet, undefined. The age-related decline of DHEAS may, partly, account for the observed 'intestinal resistance to 1,25(OH)(2)D' in older men.
Keywords: Humans
Calcium, Dietary
Dehydroepiandrosterone Sulfate
Vitamin D
Sex Hormone-Binding Globulin
Regression Analysis
Intestinal Absorption
Middle Aged
DOI: 10.1111/j.1365-2265.2008.03272.x
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