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Type: Journal article
Title: Phenotypes of the ovarian follicular basal lamina predict developmental competence of oocytes
Author: Irving-Rodgers, H.
Morris, S.
Collett, R.
Peura, T.
Davy, M.
Thompson, J.
Mason, H.
Rodgers, R.
Citation: Human Reproduction, 2009; 24(4):936-944
Publisher: Oxford Univ Press
Issue Date: 2009
ISSN: 0268-1161
Statement of
Helen F. Irving-Rodgers, Stephanie Morris, Rachael A. Collett, Teija T. Peura, Margaret Davy, Jeremy G. Thompson, Helen D. Mason and Raymond J. Rodgers
Abstract: BACKGROUND: The ovarian follicular basal lamina underlies the epithelial membrana granulosa and maintains the avascular intra-follicular compartment. Additional layers of basal lamina occur in a number of pathologies, including pili annulati and diabetes. We previously found additional layers of follicular basal lamina in a significant percentage of healthy bovine follicles. We wished to determine if this phenomenon existed in humans, and if it was related to oocyte function in the bovine. METHODS AND RESULTS: We examined follicles from human ovaries (n = 18) by electron microscopy and found that many follicles had additional layers of basal lamina. Oocytes (n = 222) from bovine follicles with normal or unusual basal laminas were isolated and their ability to undergo in vitro maturation, fertilization and culture to blastocyst was compared. Healthy bovine follicles with a single layer of basal lamina had oocytes with significantly (P < 0.01) greater developmental competence than healthy follicles with additional layers of follicular basal lamina (65% versus 28%). CONCLUSIONS: These findings provide direct evidence that the phenotype of the follicular basal lamina is related to oocyte competence.
Keywords: ovary
basal lamina
oocyte competence
in vitro production
Rights: © The Author 2008. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed: the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given: if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative word this must be clearly indicated. For commercial re-use, please contact
DOI: 10.1093/humrep/den447
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Appears in Collections:Aurora harvest
Obstetrics and Gynaecology publications

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