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Type: Journal article
Title: Differential rates of apoptosis and recruitment limit eosinophil accumulation in the lungs of asthma-resistant CBA/Ca mice
Author: Tumes, D.
Wong, A.
Sewell, W.
McColl, S.
Connolly, A.
Dent, L.
Citation: Molecular Immunology, 2008; 45(13):3609-3617
Publisher: Pergamon-Elsevier Science Ltd
Issue Date: 2008
ISSN: 0161-5890
Statement of
Damon J. Tumes, Alex C.H. Wong, William A. Sewell, Shaun R. McColl, Ashley Connolly and Lindsay A. Dent
Abstract: The accumulation of eosinophils is a common feature of allergic airway inflammation and correlates with disease severity. In an ovalbumin (OVA)-induced murine model of allergic lung disease, CBA/Ca mice develop much lower levels of lung eosinophilia, lung oedema, mucus hypersecretion and airways obstruction than BALB/c and C57BL/6 strains. In this study these strains have been examined to identify mechanisms that control the recruitment and survival of eosinophils in the allergic lung. Following immunization with OVA, CBA/Ca mice developed a robust systemic allergic response, with high levels of total and OVA-specific IgE and increases in peripheral blood eosinophils. Lung eotaxin-1 levels and expression of CD18 on eosinophils recovered by bronchoalveolar lavage (BAL) were least pronounced in CBA/Ca mice, whereas mRNA for L-selectin was highest in eosinophils from C57BL/6 mice. Apoptosis of BAL eosinophils ex vivo was most pronounced in the CBA/Ca strain. BALB/c mice expressed the highest levels of the eosinophil growth and survival factor interleukin (IL)-5 in the lungs and BAL eosinophils from these animals expressed more of the anti-apoptotic proteins Bcl-xL and Bcl-2 than cells from the other strains. A combination of lower levels of recruitment and rapid apoptosis may therefore limit the accumulation of eosinophils and pathology in the lungs of CBA/Ca mice. In addition, although the level of pathology that developed in C57BL/6 and BALB/c mice was similar, some of the underlying mechanisms are likely to differ.
Keywords: Lung
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Inbred CBA
Mice, Transgenic
Bronchial Provocation Tests
Leukocyte Count
Chemotaxis, Leukocyte
Immunity, Innate
Description: Copyright © 2008 Elsevier Ltd All rights reserved.
DOI: 10.1016/j.molimm.2008.05.002
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Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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