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Type: Journal article
Title: Distribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat
Author: Lawrenson, J.
Ghabriel, M.
Reid, A.
Gajree, T.
Allt, G.
Citation: British Journal of Ophthalmology, 1995; 79(5):462-466
Publisher: BMJ Publishing Group
Issue Date: 1995
ISSN: 0007-1161
Statement of
J G Lawrenson, Mounir N Ghabriel, A R Reid, T N Gajree, and G Allt
Abstract: BACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated.
Keywords: Eye; Orbit; Blood-Brain Barrier; Optic Nerve; Retina; Choroid; Ciliary Body; Iris; Animals; Rats; Rats, Sprague-Dawley; Antigens, Surface; Microscopy, Immunoelectron; Immunohistochemistry; Male
RMID: 0030006268
DOI: 10.1136/bjo.79.5.462
Appears in Collections:Anatomical Sciences publications

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