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|Title:||Distribution of a putative endothelial barrier antigen in the ocular and orbital tissues of the rat|
|Citation:||British Journal of Ophthalmology, 1995; 79(5):462-466|
|Publisher:||BMJ Publishing Group|
|J G Lawrenson, Mounir N Ghabriel, A R Reid, T N Gajree, and G Allt|
|Abstract:||BACKGROUND--A rat endothelial barrier antigen (EBA) recognised by a monoclonal antibody has been shown to be expressed strongly by endothelial cells of brain capillaries possessing a blood-brain barrier and only weakly expressed by fenestrated brain vessels. METHODS--In this study immunocytochemical methods for light and electron microscopy were used to study EBA distribution in the eye and orbital tissues of the rat. RESULTS--Blood-ocular barrier vessels in the optic nerve, retina, iris, and some vessels in th choroid and ciliary body were immunopositive for EBA. By pre-embedding immunocytochemistry for electron microscopy the antigen was observed on the luminal endothelial cell surface. CONCLUSION--Surprisingly, some non-barrier vessels in the ciliary body and choroid expressed EBA suggesting that it may play a broader role in endothelial properties than previously recognised. The functional significance of EBA remains to be elucidated.|
|Keywords:||Eye; Orbit; Blood-Brain Barrier; Optic Nerve; Retina; Choroid; Ciliary Body; Iris; Animals; Rats; Rats, Sprague-Dawley; Antigens, Surface; Microscopy, Immunoelectron; Immunohistochemistry; Male|
|Appears in Collections:||Anatomical Sciences publications|
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