Please use this identifier to cite or link to this item:
|Scopus||Web of Science®||Altmetric|
|Title:||Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice|
|Citation:||Journal of Bone and Mineral Research, 2008; 23(8):1182-1193|
|Publisher:||Amer Soc Bone & Mineral Res|
|Rachel A Davey, Andrew G Turner, Julie F McManus, WS Maria Chiu, Francisca Tjahyono, Alison J Moore, Gerald J Atkins, Paul H Anderson, Cathy Ma, Vaida Glatt, Helen E MacLean, Cristina Vincent, Mary Bouxsein, Howard A Morris, David M Findlay, Jeffrey D Zajac|
|Abstract:||It is well established that calcitonin is a potent inhibitor of bone resorption; however, a physiological role for calcitonin acting through its cognate receptor, the calcitonin receptor (CTR), has not been identified. Data from previous genetically modified animal models have recognized a possible role for calcitonin and the CTR in controlling bone formation; however, interpretation of these data are complicated, in part because of their mixed genetic background. Therefore, to elucidate the physiological role of the CTR in calcium and bone metabolism, we generated a viable global CTR knockout (KO) mouse model using the Cre/loxP system, in which the CTR is globally deleted by >94% but <100%. Global CTRKOs displayed normal serum ultrafiltrable calcium levels and a mild increase in bone formation in males, showing that the CTR plays a modest physiological role in the regulation of bone and calcium homeostasis in the basal state in mice. Furthermore, the peak in serum total calcium after calcitriol [1,25(OH)2D3]-induced hypercalcemia was substantially greater in global CTRKOs compared with controls. These data provide strong evidence for a biological role of the CTR in regulating calcium homeostasis in states of calcium stress.|
Mice, Inbred C57BL
Tartrate-Resistant Acid Phosphatase
|Appears in Collections:||Aurora harvest|
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.