Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/53518
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Type: Journal article
Title: Frequencies of hepatitis B and C infections among haemodialysis and peritoneal dialysis patients in Asia-Pacific countries: analysis of registry data
Author: Johnson, D.
Dent, H.
Yao, Q.
Tranaeus, A.
Huang, C.
Han, D.
Jha, V.
Wang, T.
Kawaguchi, Y.
Qian, J.
Citation: Nephrology Dialysis Transplantation, 2009; 24(5):1598-1603
Publisher: Oxford Univ Press
Issue Date: 2009
ISSN: 0931-0509
1460-2385
Statement of
Responsibility: 
David W. Johnson, Hannah Dent, Qiang Yao, Anders Tranaeus, Chiu-Chin Huang, Dae-Suk Han, Vivekanand Jha, Tao Wang, Yoshindo Kawaguchi and Jiaqi Qian.
Abstract: Background: The impact of dialysis modality on the rates and types of infectious complications has not been well studied. The aim of the present investigation was to evaluate the rates of hepatitis C virus (HCV) and hepatitis B virus (HBV) infections in peritoneal dialysis (PD) and haemodialysis (HD) patients in the Asia-Pacific region. Methods: The study included the most recent period-prevalent data recorded in the national or regional dialysis registries of the 10 Asia-Pacific countries/areas (Australia, New Zealand, Japan, China, Taiwan, Korea, Thailand, Hong Kong, Malaysia and India), where such data were available. Longitudinal data were also available for all incident Australian and New Zealand patients commencing dialysis between 1 April 1995 and 31 December 2005. Rates of HCV and HBV infections were compared by chi-square, Poisson regression and Kaplan–Meier survival analyses, as appropriate. Results: Data were obtained on 201 590 patients (HD 173 788; PD 27 802). HCV seroprevalences ranged between 0.7% and 18.1% across different countries and were generally higher in HD versus PD populations (7.9% ± 5.5% versus 3.0% ± 2.0%, P = 0.01). Seroconversion rates on dialysis were also significantly higher in HD patients (incidence rate ratio PD versus HD 0.33, 95% CI 0.13–0.75). HCV infection was highly predictive of mortality in Japan (relative risk 1.37, 95% CI 1.15–1.62, P = 0.003) and in Australia and New Zealand (adjusted hazards ratio 1.29, 95% CI 1.05–1.58). HBV infection data were limited, but less clearly influenced by dialysis modality. Conclusions: Dialysis modality selection significantly influences the risk of HCV infection experienced by end-stage renal failure patients in the Asia-Pacific region. No such association could be identified for HBV infection.
Keywords: Humans
Hepatitis B
Hepatitis C
Kidney Failure, Chronic
Renal Dialysis
Peritoneal Dialysis
Registries
Prevalence
Risk Factors
Regression Analysis
Retrospective Studies
Malaysia
Thailand
India
China
Hong Kong
Japan
Korea
Taiwan
Australia
New Zealand
Kaplan-Meier Estimate
Rights: © The Author [2008]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
DOI: 10.1093/ndt/gfn684
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