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Type: Journal article
Title: Effect of two doses of docosahexaenoic acid (DHA) in the diet of preterm infants on infant fatty acid status: Results from the DINO trial
Author: Smithers, L.
Gibson, R.
McPhee, A.
Makrides, M.
Citation: Prostaglandins Leukotrienes and Essential Fatty Acids, 2008; 79(3-5):141-146
Publisher: Churchill Livingstone
Issue Date: 2008
ISSN: 0952-3278
Statement of
L.G. Smithers, R.A. Gibson, A. McPhee and M. Makrides
Abstract: Formula supplemented with docosahexaenoic acid (DHA) improves retinal function of preterm infants but the optimal dose is unknown. In a randomized controlled trial we examined the effect of increasing the DHA concentration of human milk and formula on circulating fatty acids of preterm infants. Infants born <33 weeks gestation were fed high-DHA milk (1% total fat as DHA) or standard-DHA milk (0.2-0.3% DHA) until reaching their estimated due date (EDD). Milk arachidonic acid (AA) concentration was approximately 0.5% for both groups. At EDD, erythrocyte membrane phospholipid DHA was elevated in the high-DHA group compared with standard-DHA (mean+/-SD, high-DHA 6.8+/-1.2, standard-DHA 5.2+/-0.7, p<0.0005) but AA was lower (high-DHA 14.9+/-1.3, standard-DHA 16.0+/-1.2, p<0.0005). Feeding preterm infants human milk and formula with 1% DHA raises but does not saturate erythrocyte phospholipids with DHA. Milk exceeding 1% DHA may be required to increase DHA status to levels seen in term infants.
Keywords: Milk, Human; Humans; Body Weight; Birth Weight; Docosahexaenoic Acids; Fatty Acids; Body Height; Double-Blind Method; Infant Formula; Infant, Newborn; Infant, Premature; Female; Male
Description: Copyright © 2008 Elsevier Ltd All rights reserved.
RMID: 0020083673
DOI: 10.1016/j.plefa.2008.09.015
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Appears in Collections:Paediatrics publications

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