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Type: Journal article
Title: Bioenergetic-based neuroprotection and glaucoma
Author: Schober, M.
Chidlow, G.
Wood, J.
Casson, R.
Citation: Clinical and Experimental Ophthalmology, 2008; 36(4):377-385
Publisher: Blackwell Publishing Asia
Issue Date: 2008
ISSN: 1442-6404
Statement of
Schober Michael S, Chidlow Glyn, Wood John PM and Casson Robert J
Abstract: Primary open-angle glaucoma (POAG) is a pressure-sensitive optic neuropathy which results in the death of retinal ganglion cells and causes associated loss of vision. Presently, the only accepted treatment strategy is to lower the intraocular pressure; however, for some patients this is insufficient to prevent progressive disease. Although the pathogenesis of POAG remains unclear, there is considerable evidence that energy failure at the optic nerve head may be involved. Neuroprotection, a strategy which directly enhances the survival of neurons, is desirable, but remains clinically elusive. One particular form of neuroprotection involves the notion of enhancing the energy supply of neurons. These `bioenergetic' methods of neuroprotection have proven successful in animal models of other neurodegenerative diseases and conditions, including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis and traumatic brain injury, but have been relatively unexplored in glaucoma models. This review focuses on some of the potential approaches for bioenergetic neuroprotection in the retina, including increasing the energy buffering capacity of damaged cells, decreasing the permeability of the mitochondrial membrane pore and free radical scavenging.
Keywords: bioenergetic neuroprotection; excitotoxicity; glaucoma
Description: Website © 2008 Ingenta. Article copyright remains with the publisher, society or author(s) as specified within the article
RMID: 0020084686
DOI: 10.1111/j.1442-9071.2008.01740.x
Appears in Collections:Opthalmology & Visual Sciences publications

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