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Type: Journal article
Title: Cerebral small vessel disease - Genetic risk assessment for prevention and treatment
Author: Lam, A.
Hamilton-Bruce, M.
Jannes, J.
Koblar, S.
Citation: Molecular Diagnosis and Therapy, 2008; 12(3):145-156
Publisher: Adis International Ltd.
Issue Date: 2008
ISSN: 1177-1062
Statement of
Lam, Ada; Hamilton-Bruce, M Anne; Jannes, Jim; Koblar, Simon A
Abstract: Cerebrovascular disease is a major burden to individuals and their communities worldwide. Stroke is one of the leading causes of death and disability, and the prevention and treatment of stroke can be improved with a better understanding of its causation. Cerebral small vessel disease (SVD) is a subset of cerebrovascular disease, and has an equally large impact on an individual's quality of life. Although many risk factors are involved, we propose that genetics has a significant role in the pathogenesis of SVD through a complex interplay of environmental and multigenetic factors. Advances in molecular technology have enabled the human genome to be investigated both at a population and, more recently, an individual level. A better understanding of the molecular basis of SVD will enable the development of therapies to help in its prevention and treatment. This review assesses the molecular genetics underlying cerebral SVD.
Keywords: Microcirculation
Cerebrovascular Disorders
Genetic Predisposition to Disease
Inflammation Mediators
Hematologic Agents
Organ Size
Risk Assessment
Risk Factors
Models, Biological
Metabolic Networks and Pathways
DOI: 10.1007/BF03256279
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