Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/53871
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dc.contributor.authorPilarski, L.en
dc.contributor.authorBaigorri, E.en
dc.contributor.authorMant, M.en
dc.contributor.authorPilarski, P.en
dc.contributor.authorAdamson, P.en
dc.contributor.authorZola, H.en
dc.contributor.authorBelch, A.en
dc.date.issued2008en
dc.identifier.citationClinical Medicine: Oncology, 2008; 2:275-287en
dc.identifier.issn1177-9314en
dc.identifier.urihttp://hdl.handle.net/2440/53871-
dc.description.abstractPotential progenitor B cell compartments in multiple myeloma (MM) are clinically important. MM B cells and some circulating MM plasma cells express CD20, predicting their clearance by treatment with anti-CD20. Here we describe two types of clonotypic CD20+ B cell in peripheral blood of myeloma patients, identified by their expression of CD19 and CD20 epitopes, their expression of CD45RA and their light scatter properties. Thus, the circulating component of the MM clone includes at least two distinct CD19+ CD20+ B cell compartments, as well as CD138+CD20+ plasma cells. To determine whether either or both B cell subsets and the CD20+ plasma cell subset were depleted by anti-CD20 therapy, they were evaluated before, during and after treatment of patients with rituximab (anti-CD20), followed by quantifying B cell subsets over a 5 month period during and after treatment. Overall, all three types of circulating B lineage cells persist despite treatment with rituximab. The inability of rituximab to prolong survival in MM may result from this failure to deplete CD20+ B and plasma cells in MM.en
dc.description.statementofresponsibilityLinda M., Pilarski and Eva Baigorri, and Michael J., Mant and Patrick M., Pilarski and Penelope Adamson, and Heddy Zola, and Andrew R., Belchen
dc.description.urihttp://eprints.kfupm.edu.sa/129735/en
dc.language.isoenen
dc.publisherLibertas Academica Ltden
dc.titleMultiple Myeloma Includes Phenotypically Defined Subsets of Clonotypic CD20+ B Cells that Persist During Treatment with Rituximaben
dc.typeJournal articleen
dc.identifier.rmid0020083174en
dc.identifier.pubid41622-
pubs.library.collectionPaediatrics publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Paediatrics publications

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