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https://hdl.handle.net/2440/54120
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Type: | Journal article |
Title: | Effect of intra-articular infliximab on synovial membrane pathology in a patient with a seronegative spondyloarthropathy |
Author: | Ahern, M. Campbell, D. Weedon, H. Papangelis, V. Smith, M. |
Citation: | Annals of the Rheumatic Diseases, 2008; 67(9):1339-1342 |
Publisher: | British Med Journal Publ Group |
Issue Date: | 2008 |
ISSN: | 0003-4967 1468-2060 |
Statement of Responsibility: | M J Ahern, D G Campbell, H Weedon, V Papangelis, M D Smith |
Abstract: | Objective: To demonstrate the efficacy of intra-articular infliximab in a patient with a persistent monarthritis who had previously had two arthroscopic synovectomies with limited success, and to determine the effect of intra-articular infliximab on synovial membrane pathology Method: Arthroscopic synovial biopsy specimens were collected before and after treatment with intra-articular infliximab. The synovial tissue was stained for a range of inflammatory cell subsets, cell adhesion molecules and cytokines using immunohistochemical techniques and quantified using digital image analysis and a semiquantitative scoring method. Results: Clinical improvement in the knee synovitis was seen after the first two intra-articular infliximab treatments, with a sustained clinical remission lasting for more than 12 months after the third treatment. Significant changes in cellular infiltration and expression of cytokines and cell adhesion molecules occurred as a result of treatment with intra-articular infliximab, with a reduction in some but not all cells in the inflammatory infiltrate, as well as a reduction in the expression of cell adhesion molecules (intercellular adhesion molecule-1 and vascular adhesion molecule-1) and production of cytokines (interleukin 1β and tumour necrosis factor α). Conclusion: Intra-articular infliximab administration is a viable treatment for a persistent monarthritis resistant to other treatment options and can successfully modulate the inflammatory milieu within the synovial membrane. |
Keywords: | Synovial Membrane Humans Spondylarthropathies Synovitis Antirheumatic Agents Antibodies, Monoclonal Biopsy Injections, Intra-Articular Adult Female Infliximab |
DOI: | 10.1136/ard.2008.090910 |
Published version: | http://dx.doi.org/10.1136/ard.2008.090910 |
Appears in Collections: | Aurora harvest Orthopaedics and Trauma publications |
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