Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/54324
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Type: Conference paper
Title: Isoflurance increases cardiorespiratory coordination in rats
Author: Kabir, M.
Beig, M.
Nalivaiko, E.
Abbott, D.
Baumert, M.
Citation: Proceedings of the SPIE Smart Materials, Nano-, and Micro-Smart Systems. Proceedings of the SPIE, 2008. Vol. 7270, pp. 72700Y-7
Publisher: SPIE
Publisher Place: CD
Issue Date: 2008
Series/Report no.: Proceedings of SPIE
ISBN: 9780819475220
ISSN: 1605-7422
Conference Name: SPIE Smart Materials, Nano-, and Micro-Smart Systems (2008 : Melbourne, Australia)
Statement of
Responsibility: 
Muammar M. Kabir, Mirza I. Beig, Eugene Nalivaiko, Derek Abbott and Mathias Baumert
Abstract: Anesthetics such as isoflurane adversely affect heart rate. In this study we analysed the interaction between heart rhythm and respiration at different concentrations of isoflurane and ventilation rates. In two rats, the electrocardiogram (ECG) and respiratory signals were recorded under the influence of isoflurane. For the assessment of cardiorespiratory coordination, we analysed the phase locking between heart rate, computed from the R-R intervals of body surface ECG, and respiratory rate, computed from impedance changes, using Hilbert transform. The changes in heart rate, percentage of synchronization and duration of synchronized epochs at different isoflurane concentrations and ventilation rates were assessed using linear regression model. From this study it appears that the amount of phase locking between cardiac and respiratory rates increases with the increase in concentration of isoflurane. Heart rate and duration of synchronized epochs increased significantly with the increase in the level of isoflurane concentration while respiratory rate was not significantly affected. Cardiorespiratory coordination also showed a considerable increase at the ventilation rates of 50- 55 cpm in both the rats, suggesting that the phase-locking between the cardiac and respiratory oscillators can be increased by breathing at a particular respiratory frequency.
Description: ©2008 COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
RMID: 0020085426
DOI: 10.1117/12.810681
Appears in Collections:Electrical and Electronic Engineering publications

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