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Type: Journal article
Title: Plant CLE peptides from two distinct functional classes synergistically induce division of vascular cells
Author: Whitford, R.
Fernandez, A.
De Groodt, R.
Ortega, E.
Hilson, P.
Citation: Proceedings of the National Academy of Sciences of the United States of America, 2008; 105(47):18625-18630
Publisher: Natl Acad Sciences
Issue Date: 2008
ISSN: 0027-8424
Statement of
Ryan Whitford, Ana Fernandez, Ruth De Groodt, Esther Ortega, and Pierre Hilson
Abstract: The Clavata3 (CLV3)/endosperm surrounding region (CLE) signaling peptides are encoded in large plant gene families. CLV3 and the other A-type CLE peptides promote cell differentiation in root and shoot apical meristems, whereas the B-type peptides (CLE41–CLE44) do not. Instead, CLE41 inhibits the differentiation of Zinnia elegans tracheary elements. To test whether CLE genes might code for antagonistic or synergistic functions, peptides from both types were combined through overexpression within or application onto Arabidopsis thaliana seedlings. The CLE41 peptide (CLE41p) promoted proliferation of vascular cells, although delaying differentiation into phloem and xylem cell lineages. Application of CLE41p or overexpression of CLE41 did not suppress the terminal differentiation of the root and shoot apices triggered by A-type CLE peptides. However, in combination, A-type peptides enhanced all of the phenotypes associated with CLE41 gain-of-function, leading to massive proliferation of vascular cells. This proliferation relied on auxin signaling because it was enhanced by exogenous application of a synthetic auxin, decreased by an auxin polar transport inhibitor, and abolished by a mutation in the Monopteros auxin response factor. These findings highlight that vascular patterning is a process controlled in time and space by different CLE peptides in conjunction with hormonal signaling.
Keywords: Peptides; Plant Proteins; Cell Division; Cell Lineage; Plant Physiological Phenomena; Plant Cells; Plant Development
RMID: 0020093387
DOI: 10.1073/pnas.0809395105
Appears in Collections:Adelaide Microscopy publications
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