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Type: Journal article
Title: Uterine leiomyoma and menstrual cycle characteristics in a population-based cohort study
Author: Marino, J.
Eskenazi, B.
Warner, M.
Samuels, S.
Vercellini, P.
Gavoni, N.
Olive, D.
Citation: Human Reproduction, 2004; 19(10):2350-2355
Publisher: Oxford Univ Press
Issue Date: 2004
ISSN: 0268-1161
Statement of
J.L. Marino, B. Eskenazi, M. Warner, S. Samuels, P. Vercellini, N. Gavoni and D. Olive
Abstract: BACKGROUND: We examined the association of uterine leiomyoma with menstrual cycle characteristics in a population of non-care-seeking women. METHODS: This cross-sectional study uses data from the Seveso Women's Health Study (SWHS), a population-based cohort in Italy. Participants included 341 premenopausal women, 30–60 years old, who had an intact uterus and were not pregnant, lactating, or using oral contraception or intra-uterine devices. We examined the presence of any ultrasound-detected uterine leiomyoma in relation to self-reported menstrual cycle length, flow length and heaviness of flow. The association of leiomyoma number, volume, tissue layer location and axial position with menstrual cycle characteristics was also examined. RESULTS: Uterine leiomyomata were detected in 73 women (21.4%). After adjustment for covariates, the presence of a leiomyoma was not significantly related to menstrual cycle length, flow length or heaviness of flow [odds ratio (OR) for scanty flow =1.9, 95% confidence interval (CI) 0.8–4.3; OR for heavy flow =1.3, 95% CI 0.7–2.5; relative to moderate flow]. Number, volume, tissue layer location (subserosal or intramural) and axial position (anterior or posterior) of the leiomyoma were also not related to menstrual cycle characteristics. CONCLUSION: In this Italian population of women not seeking gynaecological care, menstrual characteristics are not related to leiomyoma.
Keywords: epidemiology
menstrual cycle
transvaginal ultrasound
DOI: 10.1093/humrep/deh407
Appears in Collections:Aurora harvest 5
Obstetrics and Gynaecology publications

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