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|Title:||Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.|
|Citation:||FEBS Letters, 2008; 582(19):2950-2956|
|Publisher:||Elsevier Science BV|
|Christopher A. McDevitt, Chitra A. Shintre, J. Günter Grossmann, Naomi L. Pollock, Stephen M. Prince, Richard Callaghan, Robert C. Ford|
|Abstract:||P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.|
|Keywords:||Multidrug resistance; Membrane protein; Protein structure; Electron crystallography; SAXS; ABCB1|
|Appears in Collections:||Molecular and Biomedical Science publications|
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