Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/54875
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Type: Journal article
Title: Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography.
Author: McDevitt, C.
Shintre, C.
Grossmann, G.
Pollock, N.
Prince, S.
Callaghan, R.
Ford, R.
Citation: FEBS Letters, 2008; 582(19):2950-2956
Publisher: Elsevier Science BV
Issue Date: 2008
ISSN: 0014-5793
1873-3468
Statement of
Responsibility: 
Christopher A. McDevitt, Chitra A. Shintre, J. Günter Grossmann, Naomi L. Pollock, Stephen M. Prince, Richard Callaghan, Robert C. Ford
Abstract: P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure.
Keywords: Multidrug resistance; Membrane protein; Protein structure; Electron crystallography; SAXS; ABCB1
RMID: 0020093483
DOI: 10.1016/j.febslet.2008.07.022
Appears in Collections:Molecular and Biomedical Science publications

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