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Type: Journal article
Title: Assessing flucloxacillin contamination and decontamination - a laboratory study
Author: Lee, S.
Jankewicz, G.
Lee, N.
Citation: Journal of Pharmacy Practice and Research, 2009; 39(2):95-98
Publisher: Society of Hospital Pharmacists of Australia
Issue Date: 2009
ISSN: 1445-937X
Statement of
Su-Gil Lee, Ganyk J. Jankewicz, Nae-Woo Lee
Abstract: Background: Flucloxacillin is a widely used antibiotic but data are lacking on the risks associated with occupational exposure. Aim: To evaluate flucloxacillin stability; to identify an effective decontamination reagent for flucloxacillin; and to identify glove material that will prevent flucloxacillin permeation. Method: Decontamination reagents used for flucloxacillin wipe sampling and degradation/stability tests included: isopropanol 50% and 70%, ethanol 60% and 100%, benzalkonium chloride 0.1% (Pine O Cleen), sodium hypochlorite 0.5% (Chloroclens), sodium hydroxide 0.03M and distilled water. Short term (0 to 90 minutes) and daily degradation (0 to 6 days) of flucloxacillin in these media and flucloxacillin recovery from surface wipe sampling was investigated using high pressure liquid chromatography with ultraviolet detection. Flucloxacillin permeation was tested using disposable, powder-free latex and nitrile gloves in a disposable test cell to which solution was applied on one side of the glove material and wiped from the other side after 3 hours. Results: This analytical method for assessing flucloxacillin contamination has a limit of detection of 0.1 microg/mL. Distilled water was the most suitable solvent as degradation of flucloxacillin was minimal. Sodium hypochlorite 0.5%, followed by sodium hydroxide 0.03M and benzalkonium chloride 0.1%, were the most effective decontamination reagents. No permeation of flucloxacillin was detected through the latex or nitrile gloves after a 3 hour period. Conclusion: A method for assessing occupational exposure to flucloxacillin is described in this paper. Sodium hypochlorite 0.5% was the most effective decontamination reagent for flucloxacillin. Both the latex and nitrile gloves prevented flucloxacillin permeation for up to 3 hours.
DOI: 10.1002/j.2055-2335.2009.tb00429.x
Published version:;dn=948784617024914;res=IELHEA
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