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Type: Journal article
Title: Pathophysiology and management of gastroparesis
Author: Khoo, J.
Rayner, C.
Jones, K.
Horowitz, M.
Citation: Expert Review of Gastroenterology and Hepatology, 2009; 3(2):167-181
Publisher: Expert Reviews Ltd.
Issue Date: 2009
ISSN: 1747-4132
Statement of
Joan Khoo, Christopher K. Rayner, Karen L. Jones and Michael Horowitz
Abstract: Gastroparesis is characterized by upper gastrointestinal symptoms associated with delayed gastric emptying, without mechanical obstruction. However, symptoms do not correlate well with the magnitude of delay in gastric emptying. Diabetes mellitus and surgery are the most common causes, although more than 30% of cases are idiopathic. Coordination of insulin action with nutrient delivery is important in diabetics, as postprandial blood glucose levels and gastric emptying are interdependent, and gastroparesis probably represents a major cause of poor glycemic control. Scintigraphy is the gold standard for measuring gastric emptying. Current treatment mainly involves the use of prokinetic drugs. Pyloric botulinum toxin injection and gastric electrical stimulation require more evidence from controlled studies before their use can be recommended. Surgical options remain inadequately studied.
Keywords: Humans; Gastroparesis; Diabetes Complications; Gastrointestinal Agents; Electric Stimulation Therapy; Feeding Behavior; Gastric Emptying
RMID: 0020091347
DOI: 10.1586/egh.09.10
Appears in Collections:Medicine publications

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