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Type: Journal article
Title: Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia
Author: Billing, K.
Karagiannis, A.
Selva-Nayagam, D.
Citation: American Journal of Ophthalmology, 2003; 136(4):746-747
Publisher: Elsevier Science Inc
Issue Date: 2003
ISSN: 0002-9394
Statement of
Kathryn Billing, Arthur Karagiannis and Dinesh Selva
Abstract: PURPOSE:To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described. DESIGN:Observational case report. METHOD:A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora. RESULTS:Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum. CONCLUSION:Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.
Keywords: Nasolacrimal Duct; Humans; Corneal Diseases; Lacrimal Duct Obstruction; Fibrosis; Mitomycin; Antibiotics, Antineoplastic; Administration, Topical; Middle Aged; Female
RMID: 0020091881
DOI: 10.1016/S0002-9394(03)00393-3
Appears in Collections:Opthalmology & Visual Sciences publications

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