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dc.contributor.authorVaccaro, S.-
dc.identifier.citationPhysical Review E: Statistical, Nonlinear, and Soft Matter Physics, 2008; 78(6 Part 1):061915-1-061915-4-
dc.description.abstractA position-dependent stochastic diffusion model of gating in ion channels is developed by considering the spatial variation of the diffusion coefficient between the closed and open states. It is assumed that a sensor which regulates the opening of the ion channel experiences Brownian motion in a closed region Rc and a transition region Rm, where the dynamics is described by probability densities pc(x,t) and pm(x,t) which satisfy interacting Fokker-Planck equations with diffusion coefficient Dc(x)=Dc exp(γcx) and Dm(x)=Dm exp(−γmx). The analytical solution of the coupled equations may be approximated by the lowest frequency relaxation, a short time after the application of a depolarizing voltage clamp, when Dm⪡Dc or the diffusion parameter γm is sufficiently large. Thus, an empirical rate equation that describes gating transitions may be derived from a stochastic diffusion model if there is a large diffusion (or potential) barrier between open and closed states.-
dc.description.statementofresponsibilityS. R. Vaccaro-
dc.publisherAmerican Physical Soc-
dc.rights©2008 American Physical Society-
dc.titlePosition-dependent stochastic diffusion model of ion channel gating-
dc.typeJournal article-
dc.identifier.orcidVaccaro, S. [0000-0003-1343-3668]-
Appears in Collections:Aurora harvest 5
Physics publications

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