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Type: Journal article
Title: Glutathione: A novel treatment target in psychiatry
Author: Berk, M.
Ng, F.
Dean, O.
Dodd, S.
Bush, A.
Citation: Trends in Pharmacological Sciences, 2008; 29(7):346-351
Publisher: Elsevier Science London
Issue Date: 2008
ISSN: 0165-6147
Statement of
Michael Berk, Felicity Ng, Olivia Dean, Seetal Dodd and Ashley I. Bush
Abstract: There is accumulating evidence for oxidative stress mechanisms as common pathophysiological pathways in diverse psychiatric disorders, which offers novel treatment targets in oxidation biology systems. Of these the glutathione system has the most favourable theoretical foundation, given its dominance as the most generic of cellular antioxidants. Clinically, this hypothesis has been supported by several recently published studies that have reported on the efficacy of N-acetylcysteine, a glutathione precursor, in the treatment of various psychiatric disorders. This article outlines the multidimensional evidence that currently exists for oxidative stress mechanisms in psychiatric disorders and specifically discusses glutathione as a promising novel therapeutic target.
Keywords: Humans
Mental Disorders
Oxidative Stress
DOI: 10.1016/
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Appears in Collections:Aurora harvest
Psychiatry publications

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