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https://hdl.handle.net/2440/5535
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Type: | Journal article |
Title: | Apoptosis in liver damage produced by tunicamycin |
Author: | Finnie, J. Read, S. Swift, J. |
Citation: | Australian Veterinary Journal, 2004; 82(1-2):87-90 |
Publisher: | Australian Veterinary Assn |
Issue Date: | 2004 |
ISSN: | 0005-0423 1751-0813 |
Abstract: | <h4>Objective</h4>To determine whether apoptosis contributes to hepatocyte loss in tunicamycin poisoning.<h4>Design</h4>Groups of four guinea pigs were given 400 microg/kg of tunicamycin subcutaneously and killed at 24 h intervals up to 72 h post-injection. Livers were examined by routine histological methods and ancillary techniques (TUNEL staining, endonuclease activation, caspase activity, and electron microscopy) to ascertain whether any hepatocyte injury was apoptotic.<h4>Results</h4>Many hepatocytes exposed to tunicamycin showed evidence of apoptosis in the form of nuclear karyorrhexis with chromatin margination and crescent formation, TUNEL-positivity, DNA laddering, elevated caspase activity and apoptotic body formation.<h4>Conclusion</h4>Tunicamycin caused the death of many hepatocytes in the livers of guinea pigs by apoptosis. |
Keywords: | Liver Animals Animals, Domestic Guinea Pigs Plant Poisoning Tunicamycin Injections, Subcutaneous In Situ Nick-End Labeling Apoptosis Animal Feed |
DOI: | 10.1111/j.1751-0813.2004.tb14652.x |
Appears in Collections: | Aurora harvest Pathology publications |
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