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Type: Journal article
Title: Apoptosis in liver damage produced by tunicamycin
Author: Finnie, J.
Read, S.
Swift, J.
Citation: Australian Veterinary Journal, 2004; 82(1-2):87-90
Publisher: Australian Veterinary Assn
Issue Date: 2004
ISSN: 0005-0423
Abstract: <h4>Objective</h4>To determine whether apoptosis contributes to hepatocyte loss in tunicamycin poisoning.<h4>Design</h4>Groups of four guinea pigs were given 400 microg/kg of tunicamycin subcutaneously and killed at 24 h intervals up to 72 h post-injection. Livers were examined by routine histological methods and ancillary techniques (TUNEL staining, endonuclease activation, caspase activity, and electron microscopy) to ascertain whether any hepatocyte injury was apoptotic.<h4>Results</h4>Many hepatocytes exposed to tunicamycin showed evidence of apoptosis in the form of nuclear karyorrhexis with chromatin margination and crescent formation, TUNEL-positivity, DNA laddering, elevated caspase activity and apoptotic body formation.<h4>Conclusion</h4>Tunicamycin caused the death of many hepatocytes in the livers of guinea pigs by apoptosis.
Keywords: Liver
Animals, Domestic
Guinea Pigs
Plant Poisoning
Injections, Subcutaneous
In Situ Nick-End Labeling
Animal Feed
DOI: 10.1111/j.1751-0813.2004.tb14652.x
Appears in Collections:Aurora harvest
Pathology publications

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