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https://hdl.handle.net/2440/5535
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DC Field | Value | Language |
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dc.contributor.author | Finnie, J. | - |
dc.contributor.author | Read, S. | - |
dc.contributor.author | Swift, J. | - |
dc.date.issued | 2004 | - |
dc.identifier.citation | Australian Veterinary Journal, 2004; 82(1-2):87-90 | - |
dc.identifier.issn | 0005-0423 | - |
dc.identifier.issn | 1751-0813 | - |
dc.identifier.uri | http://hdl.handle.net/2440/5535 | - |
dc.description.abstract | <h4>Objective</h4>To determine whether apoptosis contributes to hepatocyte loss in tunicamycin poisoning.<h4>Design</h4>Groups of four guinea pigs were given 400 microg/kg of tunicamycin subcutaneously and killed at 24 h intervals up to 72 h post-injection. Livers were examined by routine histological methods and ancillary techniques (TUNEL staining, endonuclease activation, caspase activity, and electron microscopy) to ascertain whether any hepatocyte injury was apoptotic.<h4>Results</h4>Many hepatocytes exposed to tunicamycin showed evidence of apoptosis in the form of nuclear karyorrhexis with chromatin margination and crescent formation, TUNEL-positivity, DNA laddering, elevated caspase activity and apoptotic body formation.<h4>Conclusion</h4>Tunicamycin caused the death of many hepatocytes in the livers of guinea pigs by apoptosis. | - |
dc.language.iso | en | - |
dc.publisher | Australian Veterinary Assn | - |
dc.source.uri | http://dx.doi.org/10.1111/j.1751-0813.2004.tb14652.x | - |
dc.subject | Liver | - |
dc.subject | Animals | - |
dc.subject | Animals, Domestic | - |
dc.subject | Guinea Pigs | - |
dc.subject | Plant Poisoning | - |
dc.subject | Tunicamycin | - |
dc.subject | Injections, Subcutaneous | - |
dc.subject | In Situ Nick-End Labeling | - |
dc.subject | Apoptosis | - |
dc.subject | Animal Feed | - |
dc.title | Apoptosis in liver damage produced by tunicamycin | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/j.1751-0813.2004.tb14652.x | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Finnie, J. [0000-0003-2277-1693] | - |
Appears in Collections: | Aurora harvest Pathology publications |
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