Please use this identifier to cite or link to this item:
Scopus Web of ScienceĀ® Altmetric
Type: Journal article
Title: Nano-manipulation of single DNA molecules based on atomic force microscopy
Author: Lu, Junhong
Li, Haikuo
An, Hongjie
Wang, Guo-Hua
Wang, Ying
Li, Minqian
Zhang, Yi
Li, Bin
Hu, Jun
Citation: IEEE Engineering in Medicine & Biology Society, 2005; 7:7478-7481
Publisher: IEEE
Issue Date: 2005
ISSN: 1557-170X
School/Discipline: School of Earth and Environmental Sciences
Statement of
Lu Jun-Hong, Li Hai-Kuo, An Hong-Jie, Wang Guo-Hua, Wang Ying, Li Min -Qian, Zhang Yi, Li Bin and Hu Jun
Abstract: Nano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotechnology. This paper will focus on the recent development of the manipulation of single DNA molecules based on atomic force microscopy (AFM) in our laboratory. Precise manipulation has been realized including varied manipulating modes such as "cutting", "pushing", "folding", "kneading", "picking up", "dipping", etc. The cutting accuracy is dominated by the size of the AFM tip, which is usually 10 nm or less. Single DNA fragments can be cut and picked up and then amplified by single molecule PCR. Thus positioning isolation and sequencing can be performed.
Keywords: Nano-manipulation; Single DNA molecules; Atomicforce microscopy; Molecular combing; Molecular cutting
DOI: 10.1109/IEMBS.2005.1616241
Appears in Collections:Earth and Environmental Sciences publications

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.