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https://hdl.handle.net/2440/55438
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dc.contributor.author | Murphy, K. | - |
dc.contributor.author | Chronopoulos, A. | - |
dc.contributor.author | Singh, I. | - |
dc.contributor.author | Francis, M. | - |
dc.contributor.author | Moriarty, H. | - |
dc.contributor.author | Pike, M. | - |
dc.contributor.author | Turner, A. | - |
dc.contributor.author | Mann, N. | - |
dc.contributor.author | Sinclair, A. | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | American Journal of Clinical Nutrition, 2003; 77(6):1466-1473 | - |
dc.identifier.issn | 0002-9165 | - |
dc.identifier.issn | 1938-3207 | - |
dc.identifier.uri | http://hdl.handle.net/2440/55438 | - |
dc.description | © 2003 American Society for Clinical Nutrition | - |
dc.description.abstract | Background: Flavonoids may be partly responsible for some health benefits, including antiinflammatory action and a decreased tendency for the blood to clot. An acute dose of flavanols and oligomeric procyanidins from cocoa powder inhibits platelet activation and function over 6 h in humans. Objective: This study sought to evaluate whether 28 d of supplementation with cocoa flavanols and related procyanidin oligomers would modulate human platelet reactivity and primary hemostasis and reduce oxidative markers in vivo. Design: Thirty-two healthy subjects were assigned to consume active (234 mg cocoa flavanols and procyanidins/d) or placebo (≤ 6 mg cocoa flavanols and procyanidins/d) tablets in a blinded parallel-designed study. Platelet function was determined by measuring platelet aggregation, ATP release, and expression of activation-dependent platelet antigens by using flow cytometry. Plasma was analyzed for oxidation markers and antioxidant status. Results: Plasma concentrations of epicatechin and catechin in the active group increased by 81% and 28%, respectively, during the intervention period. The active group had significantly lower P selectin expression and significantly lower ADP-induced aggregation and collagen-induced aggregation than did the placebo group. Plasma ascorbic acid concentrations were significantly higher in the active than in the placebo group (P < 0.05), whereas plasma oxidation markers and antioxidant status did not change in either group. Conclusions: Cocoa flavanol and procyanidin supplementation for 28 d significantly increased plasma epicatechin and catechin concentrations and significantly decreased platelet function. These data support the results of acute studies that used higher doses of cocoa flavanols and procyanidins. | - |
dc.description.statementofresponsibility | Karen J. Murphy, Andriana K. Chronopoulos, Indu Singh, Maureen A. Francis, Helen Moriarty, Marilyn J. Pike, Alan H. Turner, Neil J. Mann, and Andrew J. Sinclair | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Clinical Nutrition | - |
dc.source.uri | http://www.ajcn.org/cgi/content/abstract/77/6/1466 | - |
dc.subject | Blood Platelets | - |
dc.subject | Humans | - |
dc.subject | Cacao | - |
dc.subject | Catechin | - |
dc.subject | Flavonoids | - |
dc.subject | Biflavonoids | - |
dc.subject | Proanthocyanidins | - |
dc.subject | Platelet Aggregation Inhibitors | - |
dc.subject | Diet | - |
dc.subject | Time Factors | - |
dc.subject | Adult | - |
dc.subject | Middle Aged | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Dietary flavanols and procyanidin oligomers from cocoa (Theobroma cacao) inhibit platelet function | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1093/ajcn/77.6.1466 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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