Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/55504
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Type: Journal article
Title: The MerR family of transcriptional regulators
Author: Brown, N.
Stoyanov, J.
Kidd, S.
Hobman, J.
Citation: FEMS Microbiology Reviews, 2003; 27(2-3):145-163
Publisher: Elsevier Science BV
Issue Date: 2003
ISSN: 0168-6445
1574-6976
Statement of
Responsibility: 
Nigel L Brown, Jivko V Stoyanov, Stephen P Kidd and Jon L Hobman
Abstract: The MerR family is a group of transcriptional activators with similar N-terminal helix-turn-helix DNA binding regions and C-terminal effector binding regions that are specific to the effector recognised. The signature of the family is amino acid similarity in the first 100 amino acids, including a helix-turn-helix motif followed by a coiled-coil region. With increasing recognition of members of this class over the last decade, particularly with the advent of rapid bacterial genome sequencing, MerR-like regulators have been found in a wide range of bacterial genera, but not yet in archaea or eukaryotes. The few MerR-like regulators that have been studied experimentally have been shown to activate suboptimal σ70-dependent promoters, in which the spacing between the −35 and −10 elements recognised by the σ factor is greater than the optimal 17±1 bp. Activation of transcription is through protein-dependent DNA distortion. The majority of regulators in the family respond to environmental stimuli, such as oxidative stress, heavy metals or antibiotics. A subgroup of the family activates transcription in response to metal ions. This subgroup shows sequence similarity in the C-terminal effector binding region as well as in the N-terminal region, but it is not yet clear how metal discrimination occurs. This subgroup of MerR family regulators includes MerR itself and may have evolved to generate a variety of specific metal-responsive regulators by fine-tuning the sites of metal recognition.
Keywords: Activator; Gene expression; Heavy metal; Metal induction; DNA distortion
RMID: 0020092903
DOI: 10.1016/S0168-6445(03)00051-2
Appears in Collections:Molecular and Biomedical Science publications

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