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Type: Journal article
Title: A strong neuroprotective effect of the autonomous Cterminal peptide of IGF-1 Ec (MGF) in brain ischemia
Author: Dluzniewska, J.
Sarnowska, A.
Beresewicz, M.
Johnson, I.
Srai, S.
Goldspink, G.
Gorecki, D.
Zablocka, B.
Citation: The FASEB Journal, 2005; 19(13):1896-1898
Publisher: Federation Amer Soc Exp Biol
Issue Date: 2005
ISSN: 0892-6638
Statement of
Joanna Dluzniewska, Anna Sarnowska, Malgorzata Beresewicz, Ian Johnson, Surjit K. S. Srai, Bala Ramesh, Geoffrey Goldspink, Dariusz C. Górecki, and Barbara Zablocka
Abstract: The ischemic stroke is the third leading cause of death in developed countries. The C-terminal peptide of mechano-growth factor (MGF), an alternatively spliced variant of insulin-like growth factor 1 (IGF-1), was found to function independently from the rest of the molecule and showed a neuroprotective effect in vivo and in vitro. In vivo, in a gerbil model of transient brain ischemia, treatment with the synthetic MGF C-terminal peptide provided very significant protection to the vulnerable neurons. In the same model, ischemia evoked increased expression of endogenous MGF in the ischemia-resistant hippocampal neurons, suggesting that the endogenous MGF might have an important neuroprotective function. In an in vitro organotypic hippocampal culture model of neurodegeneration, the synthetic peptide was as potent as the full-length IGF-1 while its effect lasted significantly longer than that of recombinant IGF-1. While two peptides showed an additive effect, the neuroprotective action of the C-terminal MGF was independent from the IGF-1 receptor, indicating a new mode of action for this molecule. Although MGF is known for its regenerative capability in skeletal muscle, our findings demonstrate for the first time a neuroprotective role against ischemia for this specific IGF-1 isoform. Therefore, the C-terminal MGF peptide has a potential to be developed into a therapeutic modality for the prevention of neuronal damage.
Keywords: hippocampus
insulin-like growth factor 1
mechano-growth factor
Description: Published online September 6, 2005 ©2005 FASEB
DOI: 10.1096/fj.05-3786fje
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Appears in Collections:Anatomical Sciences publications
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