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Type: Journal article
Title: Precursors to damascenone: Synthesis and hydrolysis of isomeric 3,9-dihydroxymegastigma-4,6,7-trienes
Author: Puglisi, C.
Daniel, M.
Capone, D.
Elsey, G.
Prager, R.
Sefton, M.
Citation: Journal of Agricultural and Food Chemistry, 2005; 53(12):4895-4900
Publisher: Amer Chemical Soc
Issue Date: 2005
ISSN: 0021-8561
Statement of
Carolyn J. Puglisi, Merran A. Daniel, Dimitra L. Capone, Gordon M. Elsey, Rolf H. Prager, and Mark A. Sefton
Abstract: A series of four isomeric 3,9-dihydroxymegastigma-4,6,7-trienes, 8, has been prepared. The (3S,6R,9S) isomer of 8 proved to be identical to an isomer of this compound tentatively identified as an intermediate in the formation of damascenone from an allene triol. Each of the four isomers, when hydrolyzed independently of each other at pH 3.0 and 25 °C, produced product mixtures in which the major product was damascenone (1). Contrary to expectation, 3-hydroxydamascone (5) was not observed in any of the hydrolyses. Consequently, the mechanism of formation of damascenone proposed earlier requires modification. In each hydrolysis, the product mixtures showed the presence of a second isomer of 8, produced by epimerization during hydrolysis. Chiral analysis on a Cyclosil B column revealed that this epimerization was occurring at C3 in each of the hydrolyses.
Keywords: Damascenone
flavor precursors
carotenoid metabolites
acid hydrolysis
DOI: 10.1021/jf050327p
Appears in Collections:Agriculture, Food and Wine publications
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