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Type: Journal article
Title: Intratracheal administration of glucocorticoids using surfactant as a vehicle
Author: Nimmo, A.
Carstairs, J.
Patole, S.
Whitehall, J.
Davidson, K.
Vink, R.
Citation: Clinical and Experimental Pharmacology and Physiology, 2002; 29(8):661-665
Publisher: Blackwell Science Asia
Issue Date: 2002
ISSN: 0305-1870
Statement of
Alan J Nimmo, Jill R Carstairs, Sanjay K Patole, John Whitehall, Kate Davidson, Robert Vink
Abstract: 1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates. However, systemic administration of glucocorticoids to neonates is associated with significant side-effects that preclude them as an early intervention to prevent onset of the condition. Conversely, local intratracheal administration of glucocorticoids may prevent inflammatory insult to the lungs without the development of systemic side-effects. We therefore investigated whether local intratracheal delivery of corticosteroids could be facilitated using surfactant as a vehicle. 2. Addition of dexamethasone to either diluted or commercial artificial surfactant, Survanta (Abbott Industries, Sydney, NSW, Australia), did not alter the surface properties of the surfactant. 3. After intratracheal instillation to rats, radiolabelled dexamethasone in Survanta was well distributed throughout all four lobes of the lungs. A concentration gradient of the steroid was observed between the root and the peripheral sections of all lobes. 4. Our results suggest that surfactant is an effective vehicle for intratracheal delivery of glucocorticoids. Moreover, we propose that prophylactic intratracheal administration of glucocorticoids administered shortly after birth may prevent inflammatory insult to the lungs and thereby reduce the likelihood of chronic lung disease developing.
Keywords: Lung; Animals; Rats; Rats, Sprague-Dawley; Lung Diseases; Dexamethasone; Pulmonary Surfactants; Biological Products; Glucocorticoids; Surface-Active Agents; Intubation, Intratracheal; Male; Pharmaceutical Vehicles
Description: The definitive version is available at
RMID: 0020020539
DOI: 10.1046/j.1440-1681.2002.03712.x
Appears in Collections:Pathology publications

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