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dc.contributor.authorNimmo, A.en
dc.contributor.authorCarstairs, J.en
dc.contributor.authorPatole, S.en
dc.contributor.authorWhitehall, J.en
dc.contributor.authorDavidson, K.en
dc.contributor.authorVink, R.en
dc.identifier.citationClinical and Experimental Pharmacology and Physiology, 2002; 29(8):661-665en
dc.descriptionThe definitive version is available at www.blackwell-synergy.comen
dc.description.abstract1. Glucocorticoids are an effective treatment in the amelioration of chronic lung disease in neonates. However, systemic administration of glucocorticoids to neonates is associated with significant side-effects that preclude them as an early intervention to prevent onset of the condition. Conversely, local intratracheal administration of glucocorticoids may prevent inflammatory insult to the lungs without the development of systemic side-effects. We therefore investigated whether local intratracheal delivery of corticosteroids could be facilitated using surfactant as a vehicle. 2. Addition of dexamethasone to either diluted or commercial artificial surfactant, Survanta (Abbott Industries, Sydney, NSW, Australia), did not alter the surface properties of the surfactant. 3. After intratracheal instillation to rats, radiolabelled dexamethasone in Survanta was well distributed throughout all four lobes of the lungs. A concentration gradient of the steroid was observed between the root and the peripheral sections of all lobes. 4. Our results suggest that surfactant is an effective vehicle for intratracheal delivery of glucocorticoids. Moreover, we propose that prophylactic intratracheal administration of glucocorticoids administered shortly after birth may prevent inflammatory insult to the lungs and thereby reduce the likelihood of chronic lung disease developing.en
dc.description.statementofresponsibilityAlan J Nimmo, Jill R Carstairs, Sanjay K Patole, John Whitehall, Kate Davidson, Robert Vinken
dc.publisherBlackwell Science Asiaen
dc.subjectLung; Animals; Rats; Rats, Sprague-Dawley; Lung Diseases; Dexamethasone; Pulmonary Surfactants; Biological Products; Glucocorticoids; Surface-Active Agents; Intubation, Intratracheal; Male; Pharmaceutical Vehiclesen
dc.titleIntratracheal administration of glucocorticoids using surfactant as a vehicleen
dc.typeJournal articleen
pubs.library.collectionPathology publicationsen
dc.identifier.orcidVink, R. [0000-0002-4885-0667]en
Appears in Collections:Pathology publications

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