Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/56010
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Type: Journal article
Title: Oocyte peptides as paracrine tools for ovarian stimulation and oocyte maturation
Author: Mottershead, D.
Watson, A.
Citation: Molecular Human Reproduction, 2009; 15(12):789-794
Publisher: Oxford Univ Press
Issue Date: 2009
ISSN: 1360-9947
1460-2407
Statement of
Responsibility: 
David G. Mottershead and Andrew J. Watson
Abstract: Recent studies report the production and isolation of a stable bioactive recombinant human bone morphogenetic protein 15 (rhBMP15) that is appropriately processed in HEK-293 cells and activates the SMAD 1/5/8 pathway in mouse granulosa cell cultures. Further, the purified rhBMP15 induces the expression of genes associated with cumulus expansion. Thanks to recent research, we have a greater understanding of the importance of the dialogue that occurs between the oocyte and the granulosa cell layer with regard to regulating folliculogenesis and the acquisition of oocyte developmental competence and maturation. BMP15 is one of the critical components of these intra-follicular communication pathways. The production of recombinant human BMP15 is important for understanding the biochemistry of this specific pathway and for also fully understanding its functional contributions to mediating oocyte development. The production of a stable recombinant human BMP15 is also important for use in experiments aimed at optimizing ovarian stimulation protocols and in vitro oocyte maturation methods. This is required to improve oocyte and embryonic developmental competence and increase our ability to effectively use in vitro methods for animal production and the treatment of human infertility.
Keywords: growth factors
protein biochemistry
folliculogenesis
assisted reproductive technology
embryo transfer
Description: © The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
DOI: 10.1093/molehr/gap085
Appears in Collections:Aurora harvest 5
Paediatrics publications

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