Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/56013
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Type: Journal article
Title: The cortical innate immune response increases local neuronal excitability leading to seizures
Author: Rodgers, K.
Hutchinson, M.
Northcutt, A.
Maier, S.
Watkins, L.
Barth, D.
Citation: Brain, 2009; 132(9):2478-2486
Publisher: Oxford University Press
Issue Date: 2009
ISSN: 0006-8950
1460-2156
Statement of
Responsibility: 
Krista M. Rodgers, Mark R. Hutchinson, Alexis Northcutt, Steven F. Maier, Linda R. Watkins and Daniel S. Barth
Abstract: Brain glial cells, five times more prevalent than neurons, have recently received attention for their potential involvement in epileptic seizures. Microglia and astrocytes, associated with inflammatory innate immune responses, are responsible for surveillance of brain damage that frequently results in seizures. Thus, an intriguing suggestion has been put forward that seizures may be facilitated and perhaps triggered by brain immune responses. Indeed, recent evidence strongly implicates innate immune responses in lowering seizure threshold in experimental models of epilepsy, yet, there is no proof that they can play an independent role in initiating seizures in vivo. Here, we show that cortical innate immune responses alone produce profound increases of brain excitability resulting in focal seizures. We found that cortical application of lipopolysaccharide, binding to toll-like receptor 4 (TLR4), triples evoked field potential amplitudes and produces focal epileptiform discharges. These effects are prevented by pre-application of interleukin-1 receptor antagonist. Our results demonstrate how the innate immune response may participate in acute seizures, increasing neuronal excitability through interleukin-1 release in response to TLR4 detection of the danger signals associated with infections of the central nervous system and with brain injury. These results suggest an important role of innate immunity in epileptogenesis and focus on glial inhibition, through pharmacological blockade of TLR4 and the pro-inflammatory mediators released by activated glia, in the study and treatment of seizure disorders in humans.
Keywords: epilepsy; glial cells; LPS; TLR4; IL1
Rights: © The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
RMID: 0020092875
DOI: 10.1093/brain/awp177
Grant ID: http://purl.org/au-research/grants/nhmrc/465423
Appears in Collections:Pharmacology publications

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