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dc.contributor.authorGai, W.en
dc.contributor.authorYaun, H.en
dc.contributor.authorLi, Q.en
dc.contributor.authorPower, J.en
dc.contributor.authorBlumbergs, P.en
dc.contributor.authorJensen, P.en
dc.identifier.citationExperimental Neurology, 2000; 166(2):324-333en
dc.description.abstractalpha-Synuclein and ubiquitin are two Lewy body protein components that may play antagonistic roles in the pathogenesis of Lewy bodies. We examined the relationship between alpha-synuclein, ubiquitin, and lipids in Lewy bodies of fixed brain sections or isolated from cortical tissues of dementia with Lewy bodies. Lewy bodies exhibited a range of labeling patterns for alpha-synuclein and ubiquitin, from a homogeneous pattern in which alpha-synuclein and ubiquitin were evenly distributed and overlapped across the inclusion body to a concentric pattern in which alpha-synuclein and ubiquitin were partially segregated, with alpha-synuclein labeling concentrated in the peripheral domain and ubiquitin in the central domain of the Lewy body. Lipids represented a significant component in both homogeneous and concentric Lewy bodies. These results suggest that Lewy bodies are heterogeneous in their subregional composition. The segregation of alpha-synuclein to Lewy body peripheral domain is consistent with the hypothesis that alpha-synuclein is continually deposited onto Lewy bodies.en
dc.description.statementofresponsibilityW.P. Gai, H.X. Yuan, X.Q. Li, J.T.H. Power, P.C. Blumbergs, P.H. Jensenen
dc.publisherAcademic Press Inc Elsevier Scienceen
dc.subjectBrain; Neurons; Lewy Bodies; Humans; Lewy Body Disease; Parkinson Disease; Lipids; Nerve Tissue Proteins; Ubiquitins; Microscopy, Immunoelectron; Brain Chemistry; Aged; Aged, 80 and over; Middle Aged; Female; Male; Synucleins; alpha-Synuclein; In Vitro Techniquesen
dc.titleIn situ and in vitro study of colocalization and segregation of a-Synuclein, ubiquitin, and lipids in Lewy bodiesen
dc.typeJournal articleen
Appears in Collections:Pathology publications

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