Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/56698
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens |
Author: | Jones, R. Bell, J. Sader, H. Turnidge, J. Stilwell, M. |
Citation: | Diagnostic Microbiology and Infectious Disease, 2009; 63(4):434-439 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2009 |
ISSN: | 0732-8893 1879-0070 |
Statement of Responsibility: | Ronald N. Jones, Jan M. Bell, Helio S. Sader, John D. Turnidge, and Matthew G. Stilwell |
Abstract: | Doripenem, a new 1beta-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. As noted here, the spectrum and potency extended to many rarely isolated species sampled by the Doripenem Global Surveillance Program. Among the species or species groups with <or=0.14% prevalence (1959 strains tested), doripenem was active against 98.9% of Enterobacteriaceae at <or=0.5 microg/mL. Similarly, more than 90% of other rarely isolated Gram-negative species isolates (Aeromonas spp., Delftia acidovorans, Haemophilus parainfluenzae, Neisseria meningitidis, Ochrobactrum anthropi, Pasteurella multocida, Pseudomonas oryzihabitans, and Pseudomonas stutzeri) were inhibited by <or=2 microg/mL of doripenem. The low-prevalence Gram-positive pathogens were generally less doripenem susceptible with MIC(90) results at >0.25 microg/mL for all tested species except Lactococcus garvieae, Listeria monocytogenes, and Micrococcus spp. In conclusion, doripenem exhibited a very wide spectrum but variable potencies against uncommonly cultured aerobic bacterial pathogens isolated in 2003 to 2007. These results confirm the potential use of this new carbapenem for broad-spectrum empiric or directed antimicrobial therapy. |
Keywords: | Doripenem Unusual pathogens Carbapenems Broad-spectrum |
Description: | Copyright © 2009 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.diagmicrobio.2009.01.025 |
Published version: | http://dx.doi.org/10.1016/j.diagmicrobio.2009.01.025 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.