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Type: Journal article
Title: In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens
Author: Jones, R.
Bell, J.
Sader, H.
Turnidge, J.
Stilwell, M.
Citation: Diagnostic Microbiology and Infectious Disease, 2009; 63(4):434-439
Publisher: Elsevier Science Inc
Issue Date: 2009
ISSN: 0732-8893
Statement of
Ronald N. Jones, Jan M. Bell, Helio S. Sader, John D. Turnidge, and Matthew G. Stilwell
Abstract: Doripenem, a new 1beta-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. As noted here, the spectrum and potency extended to many rarely isolated species sampled by the Doripenem Global Surveillance Program. Among the species or species groups with <or=0.14% prevalence (1959 strains tested), doripenem was active against 98.9% of Enterobacteriaceae at <or=0.5 microg/mL. Similarly, more than 90% of other rarely isolated Gram-negative species isolates (Aeromonas spp., Delftia acidovorans, Haemophilus parainfluenzae, Neisseria meningitidis, Ochrobactrum anthropi, Pasteurella multocida, Pseudomonas oryzihabitans, and Pseudomonas stutzeri) were inhibited by <or=2 microg/mL of doripenem. The low-prevalence Gram-positive pathogens were generally less doripenem susceptible with MIC(90) results at >0.25 microg/mL for all tested species except Lactococcus garvieae, Listeria monocytogenes, and Micrococcus spp. In conclusion, doripenem exhibited a very wide spectrum but variable potencies against uncommonly cultured aerobic bacterial pathogens isolated in 2003 to 2007. These results confirm the potential use of this new carbapenem for broad-spectrum empiric or directed antimicrobial therapy.
Keywords: Doripenem
Unusual pathogens
Description: Copyright © 2009 Elsevier Inc. All rights reserved.
DOI: 10.1016/j.diagmicrobio.2009.01.025
Appears in Collections:Aurora harvest 5
Paediatrics publications

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