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https://hdl.handle.net/2440/56734
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Type: | Journal article |
Title: | Oral L-carnitine: Metabolite formation and hemodialysis |
Author: | Bain, M. Faull, R. Milne, R. Evans, A. |
Citation: | Current Drug Metabolism, 2006; 7(7):811-816 |
Publisher: | Bentham Science Publishers Ltd. |
Issue Date: | 2006 |
ISSN: | 1389-2002 1875-5453 |
Statement of Responsibility: | Marcus A. Bain, Randall Faull, Robert W. Milne and Allan M. Evans |
Abstract: | L-Carnitine has important roles in intermediary metabolism and patients with end-stage renal disease who are undergoing hemodialysis may develop a secondary L-carnitine deficiency. The extent of accumulation of the metabolites trimethylamine and trimethylamine-N-oxide when L-carnitine is administered orally has not been investigated previously in this population. Oral L-carnitine at a dose of 1 g daily was administered for twelve days to six patients with end-stage renal disease undergoing hemodialysis thrice weekly. Pre-dialysis plasma concentrations of L-carnitine (mean ± SD) increased significantly (P < 0.05) from day 1 (baseline; 32.4 ± 6.1 μM) to day 8 (66.1 ± 13.8 μM) remaining constant thereafter. Although plasma levels of trimethylamine remained unaltered, the pre-dialysis plasma concentrations of trimethylamine- N-oxide increased significantly (P < 0.05) from day 1 (289.1 ± 236.1 μM) to day 12 (529.0 ± 237.9 μM). The hemodialysis clearances for L-carnitine, trimethylamine and trimethylamine-N-oxide were 14.3 ± 8.2, 14.1 ± 10.6 and 12.4 ± 5.4 L/h, respectively, indicating their efficient removal by dialysis. Oral administration of L-carnitine at a dose of 1 g daily increases plasma concentrations of this substance to physiological levels in patients with end-stage renal disease who are undergoing hemodialysis. However, concerns about the possible deleterious consequences of such a dosage regimen still remain given that plasma concentrations of trimethylamine-N-oxide were continually rising and approximately doubled in a two-week period. |
Keywords: | L-Carnitine trimethylamine trimethylamine-N-oxide end-stage renal disease hemodialysis |
DOI: | 10.2174/138920006778520561 |
Description (link): | http://www.ncbi.nlm.nih.gov/pubmed/17073580 |
Appears in Collections: | Aurora harvest Public Health publications |
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