Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/56777
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dc.contributor.authorYazbek, R.-
dc.contributor.authorHowarth, G.-
dc.contributor.authorAbbott, C.-
dc.date.issued2009-
dc.identifier.citationTrends in Pharmacological Sciences, 2009; 30(11):600-607-
dc.identifier.issn0165-6147-
dc.identifier.issn1873-3735-
dc.identifier.urihttp://hdl.handle.net/2440/56777-
dc.descriptionCopyright © 2009 Elsevier Ltd. All rights reserved.-
dc.description.abstractDipeptidyl peptidase (DPP)-4 is a member of the S9b serine protease family, which also includes DPP8 and DPP9. DPP4 cleaves a number of regulatory factors, including chemokines and growth factors. DPP4 inhibitors have recently emerged as an effective treatment option for type 2 diabetes. Early in vitro studies demonstrated that DPP4 inhibitors inhibit T-cell proliferation and cytokine production, leading to their investigation in numerous pre-clinical models of inflammatory diseases, including arthritis, multiple sclerosis and inflammatory bowel disease. Recent data suggest that the early DPP4-specific inhibitors might also bind DPP8 and DPP9, thus exerting their effects through non-specific binding. This review highlights recent insights into the applicability of DPP inhibitors as novel pharmacological agents for inflammatory disease.-
dc.description.statementofresponsibilityRoger Yazbeck, Gordon S. Howarth and Catherine A. Abbott-
dc.language.isoen-
dc.publisherElsevier Science London-
dc.source.urihttp://dx.doi.org/10.1016/j.tips.2009.08.003-
dc.subjectAnimals-
dc.subjectHumans-
dc.subjectInflammation-
dc.subjectDipeptidases-
dc.subjectDrug Delivery Systems-
dc.subjectDrug Evaluation, Preclinical-
dc.subjectClinical Trials as Topic-
dc.subjectDipeptidyl-Peptidase IV Inhibitors-
dc.subjectDipeptidyl-Peptidases and Tripeptidyl-Peptidases-
dc.subjectDipeptidyl Peptidase 4-
dc.titleDipeptidyl peptidase inhibitors, an emerging drug class for inflammatory disease?-
dc.typeJournal article-
dc.identifier.doi10.1016/j.tips.2009.08.003-
pubs.publication-statusPublished-
dc.identifier.orcidHowarth, G. [0000-0001-6979-6084]-
Appears in Collections:Agriculture, Food and Wine publications
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