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Type: Journal article
Title: Regulation of stem cell pluripotency and neural differentiation by lysophospholipids
Author: Pitson, S.
Pebay, A.
Citation: NeuroSignals, 2009; 17(4):242-254
Publisher: S. Karger AG
Issue Date: 2009
ISSN: 1424-862X
Statement of
Stuart M. Pitson, Alice Pébay
Abstract: Lysophospholipids are bioactive signalling molecules able to act through the binding of their specific G-protein-coupled receptors to exert pleiotropic effects on a wide range of cells. The most widely studied signalling lysophospholipids are lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). LPA and S1P have been identified to have widespread developmental, physiological and pathological actions in the central nervous system and more recently have been shown to induce biological effects on various stem cell types. This review aims to summarise the current knowledge on LPA and S1P regulation of embryonic and neural stem cell biology.
Keywords: Ceramide
Lysophosphatidic acid
Stem cells, induced pluripotent
Progenitor cells
G-protein-coupled receptors
Signalling pathways
Neural differentiation
Description: Copyright © 2009 S. Karger AG, Basel
DOI: 10.1159/000231891
Appears in Collections:Aurora harvest 5
Molecular and Biomedical Science publications

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