Please use this identifier to cite or link to this item: http://hdl.handle.net/2440/56804
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dc.contributor.authorAvlund, M.en
dc.contributor.authorDodd, I.en
dc.contributor.authorSemsey, S.en
dc.contributor.authorSneppen, K.en
dc.contributor.authorKrishna, S.en
dc.date.issued2009en
dc.identifier.citationJournal of Virology, 2009; 83(22):11416-11420en
dc.identifier.issn0022-538Xen
dc.identifier.issn1098-5514en
dc.identifier.urihttp://hdl.handle.net/2440/56804-
dc.descriptionCopyright © 2009, American Society for Microbiology. All Rights Reserved.en
dc.description.abstractPhage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.en
dc.description.statementofresponsibilityMikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishnaen
dc.language.isoenen
dc.publisherAmer Soc Microbiologyen
dc.subjectBacteriophage lambda; Probability; Stochastic Processes; Lysogeny; Virus Activation; Game Theoryen
dc.titleWhy do phage play dice?en
dc.typeJournal articleen
dc.identifier.rmid0020093082en
dc.identifier.doi10.1128/JVI.01057-09en
dc.identifier.pubid37245-
pubs.library.collectionBiochemistry publicationsen
pubs.verification-statusVerifieden
pubs.publication-statusPublisheden
Appears in Collections:Biochemistry publications

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