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dc.contributor.authorAvlund, M.en
dc.contributor.authorDodd, I.en
dc.contributor.authorSemsey, S.en
dc.contributor.authorSneppen, K.en
dc.contributor.authorKrishna, S.en
dc.identifier.citationJournal of Virology, 2009; 83(22):11416-11420en
dc.descriptionCopyright © 2009, American Society for Microbiology. All Rights Reserved.en
dc.description.abstractPhage lambda is among the simplest organisms that make a developmental decision. An infected bacterium goes either into the lytic state, where the phage particles rapidly replicate and eventually lyse the cell, or into a lysogenic state, where the phage goes dormant and replicates along with the cell. Experimental observations by P. Kourilsky are consistent with a single phage infection deterministically choosing lysis and double infection resulting in a stochastic choice. We argue that the phage are playing a "game" of minimizing the chance of extinction and that the shift from determinism to stochasticity is due to a shift from a single-player to a multiplayer game. Crucial to the argument is the clonal identity of the phage.en
dc.description.statementofresponsibilityMikkel Avlund, Ian B. Dodd, Szabolcs Semsey, Kim Sneppen, and Sandeep Krishnaen
dc.publisherAmer Soc Microbiologyen
dc.subjectBacteriophage lambda; Probability; Stochastic Processes; Lysogeny; Virus Activation; Game Theoryen
dc.titleWhy do phage play dice?en
dc.typeJournal articleen
pubs.library.collectionBiochemistry publicationsen
Appears in Collections:Biochemistry publications

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