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Type: Journal article
Title: Cardiorespiratory response to spontaneous cortical arousals during stage 2 and rapid eye movement sleep in healthy children
Author: Baumert, M.
Kohler, M.
Kabir, M.
Kennedy, D.
Pamula, Y.
Citation: Journal of Sleep Research, 2010; 19(3):415-424
Publisher: Blackwell Publishing Ltd
Issue Date: 2010
ISSN: 0962-1105
Statement of
Mathias Baumert, Mark Kohler, Muammar Kabir, Declan Kennedy and Yvonne Pamula
Abstract: Arousal from sleep is associated with transient and abrupt cardiorespiratory changes, and elevated arousals associated with sleep disorders may trigger adverse cardiovascular sequela. In this paper, we provide the first data in children on cardiorespiratory responses to cortical arousal. Heart rate and ventilatory responses to arousal from stage 2 and rapid eye movement (REM) sleep were investigated in 40 normal, healthy Caucasian children (age: 7.7 ± 2.6 years; body mass index z-score: 0.30 ± 0.8). All children underwent overnight polysomnography studies. Cortical arousals were scored according to standard criteria. Heart rate changes were assessed over 30 s, starting 15 s prior to cortical arousal onset. Breathing rates were quantified three breaths before and after arousal onset. Arousals from stage 2 as well as REM sleep resulted in an R–R interval shortening of about 15%, independent of age and gender. The R–R interval shortening initiated at least 3 s before the cortical arousal onset. The breathing interval immediately after cortical arousal onset was significantly shortened (P < 0.001). In conclusion, cortical arousals in children are associated with an increase in breathing rate and significant heart rate accelerations, which typically precede the cortical arousal onset.
Keywords: arousal; breathing rate; children; heart rate; sleep
Rights: © 2009 European Sleep Research Society
RMID: 0020095353
DOI: 10.1111/j.1365-2869.2009.00798.x
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Appears in Collections:Paediatrics publications

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