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Type: Journal article
Title: Delayed recruitment of lymphocytes into the lungs of CD30-deficient mice during aerogenic Mycobacterium avium infections
Author: Florido, M.
McColl, S.
Appelberg, R.
Citation: Immunobiology, 2009; 214(8):643-652
Publisher: Urban & Fischer Verlag
Issue Date: 2009
ISSN: 0171-2985
Statement of
Manuela Flórido, Shaun R. McColl and Rui Appelberg
Abstract: CD30 is a member of the tumor necrosis factor-receptor superfamily, a group of receptors known to act as accessory molecules in the development of the immune response. Control and CD30-deficient mice were aerogenically infected with Mycobacterium avium. Although the mycobacterial loads in the lungs were similar in both strains of mice, CD30-deficient animals exhibited delayed structuring of pulmonary granulomas and reduced recruitment of lymphocytes throughout a 240 days period of infection. Discrete alterations in the chemokine network were detected in the CD30-deficient animals although they showed no clear relation to the deficient inflammatory response. Thus CD30/CD153 interactions are involved in lung immune-mediated inflammation.
Keywords: Mycobacteria; T cells; Cell-mediated immunity; Lung
Description: Copyright © 2009 Elsevier GmbH All rights reserved.
RMID: 0020091239
DOI: 10.1016/j.imbio.2008.12.002
Appears in Collections:Molecular and Biomedical Science publications

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